Results 101 to 110 of about 19,549,248 (348)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Optimized Method for Generating and Acquiring GPS Gold Codes
International Journal of Antennas and Propagation, 2015 We propose a simpler and faster Gold codes generator, which can be efficiently initialized to any desired code, with a minimum delay. Its principle consists of generating only one sequence (code number 1) from which we can produce all the other different
Khaled Rouabah +4 more
doaj +1 more source
Possibility of maximum paralleling of problems on associative processors [PDF]
, 1982 M. M. Lebedinskii
openalex +1 more source
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
To see or not to see: the parallel processing of self-relevance and facial expressions. [PDF]
Cogn Res Princ Implic, 2023 Liu T, Sui J, Hildebrandt A.
europepmc +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Heterogeneity in the vascular endothelium enables parallel processing of multiple stimuli
, 2020 Matthew David Lee
openalex +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Engineering Applications of Computational Fluid MechanicsRod bundles are vital components in nuclear reactors, where flow behaviour directly affects operational safety. Accurate and efficient simulation of such flows is therefore essential.
Hang Zou +7 more
doaj +1 more source