Results 141 to 150 of about 677,509 (341)

机构设计与优化在小家电中的应用研究

open access: yesJixie chuandong, 2011
Taking the mechanism design of several typical small household appliances as an example,such as the semi-automatic coffee machine,the cookie machine,the mode of innovative thinking of the mechanism design in the small household appliances is refined ...
朱秀娟
doaj  

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

open access: yesFEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik   +6 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Defeasible logic programming: language definition, operational semantics, and parallelism

open access: yesJournal of Computer Science and Technology, 2001
This thesis defines Defeasible Logic Programming and provides a concrete specification of this new language through its operational semantics. Defeasible Logic Programming, or DeLP for short, has been defined based on the Logic Programming paradigm and ...
Alejandro Javier García
doaj  

Why human connection is the true metric of research success

open access: yesFEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan   +3 more
wiley   +1 more source

An assessment of large language models for OpenMP-based code parallelization: a user perspective

open access: yesJournal of Big Data
Large language models have sparked a lot of attention in the research community in recent days, especially with the introduction of practical tools such as ChatGPT and Github Copilot.
Marko Mišić, Matija Dodović
doaj   +1 more source

Parallelism in Constraint Programming. [PDF]

open access: yes, 2011
Writing efficient parallel programs is the biggest challenge of the software industry for the foreseeable future. We are currently in a time when parallel computers are the norm, not the exception. Soon, parallel processors will be standard even in cell phones.
openaire   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

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