Results 121 to 130 of about 103,699 (311)
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
A semantics and implementation of a causal logic programming language
, 2009 The increasingly widespread availability of multicore and manycore computers demands new programming languages that make parallel programming dramatically easier and less error prone.
Cleary, John G. +2 more
core
Building a Consistent Taxonomy for Parallel Programming Models
, 2017 Parallel programming has been a challenge for developers and software engineers for over two decades now. To lower the complexity of parallel programs, a lot of different parallel programming models (like ACTORs) or supporting libraries (like MPI) have ...
Nestmann, Markus
core +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
On the parallel real-time applications
Nauka ta progres transportu, 2012 We consider a system of parallel programming to implement real-time applications in the railway transport management. The choice of optimal programming system is substantiated.
A.M. Largina
doaj
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
A Parallel semantics for normal logic programs plus time
, 2013 It is proposed that Normal Logic Programs with an explicit time ordering are a suitable basis for a general purpose parallel programming language. Examples show that such a language can accept real-time external inputs and outputs, and mimic assignment ...
Cleary, John G. +2 more
core