Results 101 to 110 of about 103,699 (311)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Verification of Program Parallelization [PDF]
, 2018 This thesis presents a set of verification techniques based on permission-based separation logic to reason about the data race freedom and functional correctness of program parallelizations. Our reasoning techniques address different forms of high-level and low-level parallelization.
openaire +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Resource Optimization Via Structured Parallel Programming
, 1993 When dealing with massively parallel architectures, many difficult problems have to be solved. In this paper we will show how, by adopting a structured style of programming and a set of template-based compiling tools, most of the burden required in ...
B. Bacci +5 more
core +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Scalable data abstractions for distributed parallel computations
, 2012 The ability to express a program as a hierarchical composition of parts is an essential tool in managing the complexity of software and a key abstraction this provides is to separate the representation of data from the computation.
Hollis, Simon J. +2 more
core
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Some methodological issues in the design of CIAO - A generic, parallel concurrent constraint system
, 1994 We informally discuss several issues related to the parallel execution of logic programming systems and concurrent logic programming systems, and their generalization to constraint programming.
Hermenegildo, Manuel V.
core
Distance: a New Metric for Controlling Granularity for Parallel Execution [PDF]
, 1997 Granularity control is a method to improve parallel execution performance by limiting excessive parallelism. The general idea is that if the gain obtained by executing a task in parallel is less than the overheads required to support parallel execution ...
Santos Costa, Vitor +8 more
core
Journal of Computer Science and Technology, 2018 Given the availability of computer clusters based on multi-core processors, the hybrid programming model has become an important ally of high-performance computing users in improving the performance of their parallel applications.
André Luiz Lima da Costa +1 more
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