Results 41 to 50 of about 36,354 (268)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Algorithm for automatic loop parallelization for graphics processing units
, 2018 Parallelization of loop operators is a long standing problem of parallel programming. The widespread use of graphics processing units for computational tasks has resulted in the new statement of the mentioned problem for this class of multicore systems ...
Beketov, O.G. +2 more
core
Parallel algorithms for series parallel graphs [PDF]
, 1996 In this paper, a parallel algorithm is given that, given a graph G=(V, E), decides whether G is a series parallel graph, and if so, builds a decomposition tree for G of series and parallel composition rules. The algorithm uses O(log¦E¦log*¦E¦) time and O(¦E¦) operations on an EREW PRAM, andO(log¦E¦) time and O(¦E¦) operations on a CRCW PRAM (note that ...
Hans L. Bodlaender, Babette de Fluiter
openaire +4 more sources
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Overview of an Interprocedural Automatic Parallelization System
, 1995 We present an overview of our interprocedural analysis system, which applies the program analysis required for parallelization across procedure boundaries.
Parallelization System +5 more
core
FEBS Letters, EarlyView.The pyruvate generator, which causes activation of respiration by extra‐mitochondrial Ca2+, is also present and functional in rat brainstem mitochondria, as it is in other brain regions. This finding is confirmed by experiments with a fully reconstituted malate–aspartate shuttle (MAS).
Grazyna Debska‐Vielhaber +7 more
wiley +1 more source
Parallel Computation of the ICCG Method
, 2006 P(論文)Various types of numerical analysis methods for electromagnetic problems have been established and finite element methods and integral equation methods are practically used in the design of electrical machines.
坪井, 始 +5 more
core
Parallelizing scientific code with invasive interactive parallelization
, 2008 We present a case study of parallelizing serial legacy code using Invasive Interactive Parallelization (IIP) - a compositional approach to parallelizing code refactoring rooted in the Invasive Software Composition (ISC) and the Separation of Concerns ...
Kessler, Christoph, +5 more
core +1 more source
Automatically Tuning Parallel and Parallelized Programs [PDF]
, 2010 In today's multicore era, parallelization of serial code is essential in order to exploit the architectures' performance potential. Parallelization, especially of legacy code, however, proves to be a challenge as manual efforts must either be directed towards algorithmic modifications or towards analysis of computationally intensive sections of code ...
Dave, Chirag, Eigenmann, Rudolf
openaire +2 more sources