Results 61 to 70 of about 184,624 (268)

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

An Adaptive Hyperfine Spectrum Extraction Algorithm for Optical Sensing Based on SG Filtering and VMD

Sensors
In optical sensing, signal demodulation often degrades fine spectral data, particularly in spectroscopic measurements affected by Doppler noise, aliasing, and circuit noise.
Yupeng Wu, Kai Ma, Ziyan Yun, Yueheng Zhang, Qiming Su, Xinxin Kong, Zhou Wu, Wenxi Zhang   +7 more
doaj   +1 more source

Polygenic adaptation: From sweeps to subtle frequency shifts. [PDF]

PLoS Genetics, 2019
Evolutionary theory has produced two conflicting paradigms for the adaptation of a polygenic trait. While population genetics views adaptation as a sequence of selective sweeps at single loci underlying the trait, quantitative genetics posits a ...
Ilse Höllinger, Pleuni S Pennings, Joachim Hermisson   +2 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

IMPROVED SHARK SMELL OPTIMIZATION WITH ADAPTIVE PARAMETER SCHEDULING FOR FUZZY CONTROLLER TUNING

Academy Journal of Science and Engineering
This paper proposes an Improved Shark Smell Optimization (ISSO) algorithm with adaptive parameter scheduling for optimal tuning of fuzzy controller parameters in inverted pendulum stabilization.
Jin-Hyok Choe, Gwang Choe, Son-Il Kwak, Hyok-Gi Chae, Hyon-U Kong   +4 more
doaj   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Mamba-DQN: Adaptively Tunes Visual SLAM Parameters Based on Historical Observation DQN

Applied Sciences
The parameter configuration of traditional visual SLAM algorithms usually relies on expert experience and extensive experiments, and the parameter configuration needs to be reset as the scene changes, which is a complex and tedious process.
Xubo Ma, Chuhua Huang, Xin Huang, Wangping Wu   +3 more
doaj   +1 more source

Automatic design of mutation parameter adaptation for differential evolution [PDF]

ITM Web of Conferences
In this paper the Efficient Global Optimization algorithm is applied to design the adaptation strategy for mutation parameter in Differential Evolution.
Vladimir Stanovov, Semenkin Eugene
doaj   +1 more source

Data-driven adaptive setting algorithm for coiling temperature model parameter

工程科学学报, 2020
To improve the coiling temperature control accuracy for change-over strip or the first coil of batch hot-rolling, data mining technology was adopted to infer the water cooling learning coefficient which is used in coiling temperature model preset for ...
Liang-gui PENG, Deng-gang WANG, Jie LI, Jun-fang XING, Dian-yao GONG   +4 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source