Results 81 to 90 of about 184,624 (268)

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

A Reinforcement Learning Handover Parameter Adaptation Method Based on LSTM-Aided Digital Twin for UDN. [PDF]

Sensors (Basel), 2023
He J, Xiang T, Wang Y, Ruan H, Zhang X.
europepmc   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

A Unified Parameter-Adaptive MPC Framework for Motion Control of Heterogeneous AGVs with Different Actuation Topologies

Actuators
The deployment of heterogeneous Automated Guided Vehicles (AGVs) in smart manufacturing requires control strategies that can accommodate distinct actuation characteristics and constraints.
Shengyu Zhou, Yixin Su, Huawei Zhang, Zhaoqi Kang   +3 more
doaj   +1 more source

Fuzzy dynamic parameter adaptation in the bird swarm algorithm for neural network optimization. [PDF]

Soft comput, 2022
Melin P, Miramontes I, Carvajal O, Prado-Arechiga G.   +3 more
europepmc   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Lottery Rank-Pruning Adaptation Parameter Efficient Fine-Tuning

Mathematics
Recent studies on parameter-efficient fine-tuning (PEFT) have introduced effective and efficient methods for fine-tuning large language models (LLMs) on downstream tasks using fewer parameters than required by full fine-tuning.
Juhyeong Kim, Gyunyeop Kim, Sangwoo Kang
doaj   +1 more source

Nonlocal Means Image Denoising With Minimum MSE-Based Decay Parameter Adaptation

IEEE Access, 2019
Nonlocal means (NLM), a patch-based nonlocal recovery paradigm, has attracted much attention in recent decades. The decay parameter will greatly affect restoration performance of the NLM method.
Yi Zhan, Jinbo Wu, Mingyue Ding, Xuming Zhang   +3 more
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Parameter-Efficient Adaptation of Qwen2.5 for Aspect-Based Sentiment Analysis Using Low-Rank Adaptation and Parameter-Efficient Fine-Tuning

Engineering Proceedings
Aspect-based sentiment analysis (ABSA) plays a vital role in deriving fine-grained sentiment from textual content. As large language models (LLMs) are increasingly adopted for automated data annotation in natural language processing (NLP), concerns have ...
Pei Ying Lim, Chuk Fong Ho, Chi Wee Tan
doaj   +1 more source