Results 91 to 100 of about 2,795,142 (309)

Fuzzy dynamic parameter adaptation in the bird swarm algorithm for neural network optimization. [PDF]

Soft comput, 2022
Melin P, Miramontes I, Carvajal O, Prado-Arechiga G.   +3 more
europepmc   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Important role of genetic drift in rapid polygenic adaptation

Ecology and Evolution, 2020
We analyzed a model to determine the factors that facilitate or limit rapid polygenic adaptation. This model includes population genetic terms of mutation and both directional and stabilizing selection on a highly polygenic trait in a diploid population ...
Sona John, Wolfgang Stephan
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Climate change adaptation in industry and business [PDF]

, 2013
This report delivers a best practice framework to integrate financial risk assessment, governance and disclosure with existing governance principles around climate change adaptation.AbstractThe Australian business community has long been aware of the ...
Jason West, David Brereton
core  

Observer-Based Remote Conductivity Variable-Parameter Sliding Mode Control for Water–Fertilizer Integration Machines Using Recursive Least Squares Adaptive Estimation

Applied Sciences
In remote conductivity control for water–fertilizer integration systems, challenges such as long-distance nonlinearities and variable parameters can lead to fertilization inaccuracies, including over-irrigation and uneven distribution, affecting both ...
Peng Zhang, Zhigang Li, Xue Hu, Lixin Zhang   +3 more
doaj   +1 more source

Harmony Search Based Parameter Ensemble Adaptation for Differential Evolution

Journal of Applied Mathematics, 2013
In differential evolution (DE) algorithm, depending on the characteristics of the problem at hand and the available computational resources, different strategies combined with a different set of parameters may be effective.
Rammohan Mallipeddi
doaj   +1 more source

PARAMETER ADAPTATION FOR ANT COLONY SYSTEM IN WIRELESS SENSOR NETWORK

Journal of ICT, 2019
The Ant Colony System (ACS) algorithm has been applied in solving packet routing problems in Wireless Sensor Networks (WSNs). Solving these problems is complicated as packets need to be submitted through sensor nodes which are spatially distributed and ...
Husna Abdul Nasir, Ku Ku-Mahamud, Eiji Kamioka   +2 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source