Results 91 to 100 of about 393,308 (312)

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Statistical MOSFET Parameter Extraction with Parameter Selection for Minimal Point Measurement [PDF]

, 2013
A method to statistically extract MOSFET model parameters from a minimal number of transistor I(V) characteristic curve measurements, taken during fabrication process monitoring.
Alisjahbana, Marga; Institut Teknologi Indonesia
core   +2 more sources

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

MODELLING OF SUPERCRITICAL CARBON DIOXIDE EXTRACTION OF ANDROGRAPHOLIDE FROM ANDROGRAPHIS PANICULATA LEAVES BY EMPLOYING INTEGRAL DESORPTION CONCEPT [PDF]

, 2006
Mathematical formulation is necessary for the optimisation and scale-up of a separation unit such as the extraction of biomolecules from their natural resources.
Kumoro, A.C., Hasan, M., Kumoro, Andri Cahyo   +2 more
core  

Improved PiN Diode Circuit Model with Automatic Parameter Extraction Technique [PDF]

, 1997
An improved version of a recently proposed PIN diode circuit model is proposed. The most appealing feature of this model is the easy parameter extraction procedure, that requires neither an in-depth knowledge of device manufacturing, nor particularly ...
NAPOLI, ETTORE, STROLLO, ANTONIO GIUSEPPE MARIA   +1 more
core   +1 more source

A MIC-LSTM based parameter extraction method for single-diode PV model

Frontiers in Energy Research
In recent years, the installed capacity of renewable energy systems has seen rapid growth, particularly in photovoltaic (PV) power. Photovoltaic modules, being the fundamental elements of the PV system, play a crucial role in determining system ...
Xiaobo Hao, Pengcheng Liu, Yanhui Deng, Xiangjian Meng   +3 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

On Using Physical Analogies for Feature and Shape Extraction in Computer Vision [PDF]

, 2011
There is a rich literature of approaches to image feature extraction in computer vision. Many sophisticated approaches exist for low- and for high-level feature extraction but can be complex to implement with parameter choice guided by experimentation ...
Hurley, David, Nixon, Mark, Liu, Xin, Direkoglu, Cem   +3 more
core  

Parameter Extraction of Solar Photovoltaic Modules Using Gravitational Search Algorithm [PDF]

, 2016
Parameter extraction of a solar photovoltaic system is a nonlinear problem. Many optimization algorithms are implemented for this purpose, which failed in giving better results at low irradiance levels.
J. Belwin Edward, K. Ravi, K. Sathish Kumar, Avagaddi Prasad, R. Sarjila   +4 more
core   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source