Results 141 to 150 of about 393,308 (312)
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
A series resistance extraction method for health evaluation of photovoltaic modules
Frontiers in Energy ResearchPhotovoltaic (PV) modules must be monitored and evaluated in real-time during long-term operations to maintain a high performance, and series resistance is a critical component of this process.
Shinong Wang +8 more
doaj +1 more source
Astrocyte heterogeneity in brain metastases
Molecular Oncology, EarlyView.Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver +2 more
wiley +1 more source
Post-manoeuvre and online parameter estimation for manned and unmanned aircraft [PDF]
, 2013 Parameterised analytical models that describe the trimmed inflight behaviour of classical aircraft have been studied and are widely accepted by the flight dynamics community.
Jameson, Pierre-Daniel
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Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
BuildingsThe opening and closing of openable leaves constitute a key performance characteristic of door, window and curtain wall products, and the accurate extraction of opening and closing parameters is crucial for characterizing their operational capabilities ...
Hong Dong +7 more
doaj +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
A Neural Network Approach for Parameterizations of Hot Carrier Degradation Models
IEEE Journal of the Electron Devices SocietyThis study develops a parameter extraction flow for Hot Carrier Degradation (HCD) model in advanced technology based on the neural network (NN). Four types of parameters of the BSIM-CMG model are proposed to comprehensively capture the aged device ...
Cong Shen +5 more
doaj +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
Modeling and Parameter Extraction of Test Fixtures for MOSFET On-Wafer Measurements up to 60 GHz [PDF]
, 2013 We present a circuit model and parameter determination methodology for test fixtures used for on-wafer S-parameter measurements on CMOS devices. The model incorporates the frequency dependence of the series resistances and inductances due to the skin ...
Reydezel Torres Torres +2 more
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