Results 131 to 140 of about 560,784 (316)

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

open access: yesMolecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens   +6 more
wiley   +1 more source

Parameter Estimation in Linear Differential-Algebraic Equations [PDF]

open access: yes, 2003
This report describes how parameter estimation can be performed in linear DAE systems. Both time domain and frequency domain identification are examined. The results are exemplified on a small system. A potential application for the algorithms is to make
Glad, Torkel,   +2 more
core  

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

open access: yesMolecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi   +14 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

open access: yesMolecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir   +13 more
wiley   +1 more source

Identification of Linear Parameter-Varying Models with Unknown Parameter Dependence Using ϵ-Support Vector Regression [PDF]

open access: yes, 2018
The bias-variance trade-off is very sensitive to the prior selection of functional dependencies when identifying linear parameter-varying (LPV) systems. To counteract this difficulty, various non-parametric methods have been recently proposed.
Schulz, Erik   +2 more
core  

Parameter identification of PLL for grid‐connected inverter based on parameter sensitivity analysis

open access: yesIET Power Electronics
Under the condition of weak grid, the phase‐locked loop (PLL) is one of the main reasons for the sub‐synchronous oscillation of the grid‐connected inverter.
Fei Li   +6 more
doaj   +1 more source

Distributed Parameter Identification Framework Based on Intelligent Algorithms for Permanent Magnet Synchronous Wind Generator

open access: yesEnergies
Parameter identification of a permanent magnet synchronous wind generator (PMSWG) is of great significance for condition monitoring, fault diagnosis, and robust control.
Xiaoxuan Wu, De Tian, Huiwen Meng, Yi Su
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

ON THE DYNAMICS OF COMMERCIAL FISHING AND PARAMETER IDENTIFICATION [PDF]

open access: yes
This paper has two main objectives. The first is to develop a dynamic model of commercial fisheries different from most existing models that assume optimizing behavior. The industry is assumed to have a well-defined index of performance.
Ussif, Al-Amin M.   +2 more
core   +1 more source

Parameter Studies of Moving Force Identification in Laboratory [PDF]

open access: yes, 1999
The parameters of both vehicle and bridge play an important role in moving force identification. This paper aims to investigate the effect of various parameters on Time Domain Method (TDM) and Frequency- Time Domain Method (FTDM).
Chan, Tommy H.T.   +3 more
core  

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