Results 131 to 140 of about 12,666,425 (359)
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
Multidisciplinary design optimization framework for the pre design stage [PDF]
, 2010 Presented is a novel framework for performing flexible computational design studies at preliminary design stage. It incorporates a workflow management device (WMD) and a number of advanced numerical treatments, including multi-objective optimization ...
Balachandran, Libish Kalathil +11 more
core +1 more source
Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system
FEBS Open Bio, EarlyView.An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková +3 more
wiley +1 more source
Penalty functions with a small penalty parameter [PDF]
, 2002 In this article, we study the nonlinear penalization of a constrained optimization problem and show that the least exact penalty parameter of an equivalent parametric optimization problem can be diminished.
Rubinov, AM +5 more
core +1 more source
Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum
FEBS Open Bio, EarlyView.Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik +6 more
wiley +1 more source
Parameter estimation for non-linear systems: an application to vehicle dynamics [PDF]
, 2009 This work presents an investigation into the parameter estimation of suspension components and the vertical motions of wheeled vehicles from experimental data.
Pedchote, C.
core
PARAMETER OPTIMIZATION OF AUTOMATIC IGNITION CONTROL SYSTEM [PDF]
Avtomobilʹnyj Transport (Harʹkov), 2009 The method of optimum parameters obtaining of the automatic ignition control system is developed. The optimization is carried out according to the quality factor which includes ecological and performance characteristics of vehicle that allows to adapt ...
A. Dziubenko
doaj
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Comparison of Direct Multiobjective Optimization Methods for the Design of Electric Vehicles [PDF]
, 2006 "System design oriented methodologies" are discussed in this paper through the comparison of multiobjective optimization methods applied to heterogeneous devices in electrical engineering.
Régnier, Jérémi +3 more
core
FEBS Open Bio, EarlyView.Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley +1 more source