Results 111 to 120 of about 1,558,397 (342)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Solar Power Satellite antenna phase control system hardware simulation, phase 4. Volume 2: Analytical simulation of SPS system performance [PDF]

open access: yes
The pilot signal parameter optimization and power transponder analyses are presented. The SPS antenna phase control system is modeled and the hardware simulation study described.
Chie, C. M.   +2 more
core   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

open access: yesFEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Printing Parameter Optimization of Biodegradable PLA Stent Strut Thickness by using Response Surface Methodology (RSM)

open access: diamond, 2020
Amirul Asyraf Azli   +5 more
openalex   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

Optimizing farm parameters

open access: yesHerald of Dagestan State Technical University. Technical Sciences
Objective. This article examines the operational characteristics of trusses with the aim of determining the optimal number of different elements in truss design. Method.
A. K. Yusupov   +3 more
openaire   +1 more source

Parameter Optimization in Automatic Transcription of Music [PDF]

open access: yes
Based on former work on automatic transcription of musical time series into sheet music (Ligges et al. (2002), Weihs and Ligges (2003, 2005)) in this paper parameters of the transcription algorithm are optimized for various real singers.
Ligges, Uwe, Weihs, Claus
core  

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

open access: yesFEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee   +3 more
wiley   +1 more source

Optimal Control System with Optimal Parameters

open access: yesTransactions of the Japan Society of Mechanical Engineers, 1969
The optimal control problems are extended to the case which includes plant parameters not only in the dynamics of plant and performance functional but also in the constraints of control input. The plant parameters are, for example, heat transfer surface area, horse power of motors, size of control valves, etc.
Masami MASUBUCHI   +2 more
openaire   +2 more sources

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