Results 101 to 110 of about 1,558,397 (342)

Study on the Impact of Input Parameters on Seawater Dissolved Oxygen Prediction Models

open access: yesJournal of Marine Science and Engineering
The concentration of dissolved oxygen (DO) in seawater is a core ecological indicator in aquaculture, and its accurate prediction is of great value for the management of marine ranching.
Wenqing Li   +3 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

open access: yesFEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

The Art-of-Hyper-Parameter Optimization with Desirable Feature Selection [PDF]

open access: green, 2021
Priynka Sharma   +2 more
openalex   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

open access: yesFEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková   +3 more
wiley   +1 more source

Interactive parameter optimization characteristics of hydrological models based on Large Language Models: a case study of the HBV and VIC models

open access: yesShui kexue jinzhan
Complex distributed hydrological models based on physical factors involve high computational costs,and it is difficult to apply conventional global optimization algorithms to these models because of the large number of model simulations required ...
Yehai TANG   +6 more
doaj   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

open access: yesFEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik   +6 more
wiley   +1 more source

Parameter Adaptive Manta Ray Foraging Optimization for Global Continuous Optimization Problems and Parameter Estimation of Solar Photovoltaic Models

open access: yesInternational Journal of Computational Intelligence Systems
The manta ray foraging optimization (MRFO) algorithm suffers from a fixed parameter $$ S $$ S , limiting its adaptability in balancing search capability and convergence speed during different optimization stages.
Zhentao Tang   +8 more
doaj   +1 more source

Optimizing Test Setup Parameters for Force Appropriation Testing

open access: gold, 2023
Nehemiah Mork   +6 more
openalex   +1 more source

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