Results 91 to 100 of about 12,666,425 (359)

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

System identification in production ecology: from theory to agroforestry practice [PDF]

, 2009
This paper introduces a system identification approach to agricultural ecosystems. In particular, the identification of an agroforestry system, combining trees with crops, is subject of study.
Graves, Anil R., Keesman, K.J., Graves, A., Karel J. Keesman, Anil Graves, van der Werf, Wopke, Keesman, K. J., Wopke van der Werf, Werf, W., van der, Burgess, Paul J., Burgess, P., Paul Burgess, van der Werf, W.   +12 more
core   +1 more source

Research Prospects for the Optimization of Magneto-Optical Trap Parameters for Cold Atom Interferometers

Applied Sciences
This study examines parameter optimization for magneto-optical traps (MOTs) to increase trapping efficiency and improve cold atom interferometer performance.
Dongyi Li, Fangjun Qin, Rui Xu, An Li
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Evolutionary optimization of echo state networks: multiple motor pattern learning [PDF]

, 2010
Krause AF, Dürr V, Bläsing B, Schack T. Evolutionary optimization of echo state networks: multiple motor pattern learning. In: Artificial neural networks and intelligent information processing : proceedings of the 6th International Workshop on ...
Krause, André Frank, Bläsing, Bettina, Schack, Thomas, Dürr, Volker ; https://orcid.org/   +3 more
core   +2 more sources

An Interactive Approach for Hierarchical Parameter Optimization

Journal of Fluid Science and Technology, 2008
We propose a novel interactive parameter optimization technique which asks users to determine whether further exploration is required by using a hierarchical visualization technique. Our technique generates a k-d tree and uses the coefficient of multiple
Teppei TANAKA, Takayuki ITOH, Naohisa SAKAMOTO, Koji KOYAMADA   +3 more
doaj   +1 more source

Seismic Model Parameter Optimization for Building Structures

Sensors, 2020
Structural dynamic modeling is a key element in the analysis of building behavior for different environmental factors. Having this in mind, the authors propose a simple nonlinear model for studying the behavior of buildings in the case of earthquakes ...
Lengyel Károly, Ovidiu Stan, Liviu Miclea   +2 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Parameter Calibration for Optimization under Uncertainty [PDF]

, 2018
Optimization formulations to handle decision-making under uncertainty often contain parameters needed to be calibrated from data. Examples include uncertainty set sizes in robust optimization, and Monte Carlo sample sizes in constraint sampling or ...
Lam, Henry
core  

Process parameter optimization for lateral flow immunosensing

Materials Science for Energy Technologies, 2019
Lateral flow immunoassay (LFIA) is a widely used technique in the field of point-of-care diagnostics. Assembly of components such as sample pad, conjugate pad, nitrocellulose membrane (NCM), absorbent pad on the plastic backing laminate to prepare the ...
Vivek Borse, Rohit Srivastava
doaj   +1 more source