Results 71 to 80 of about 331,515 (268)

Whale optimization algorithm with nonlinear control parameter

open access: yesMATEC Web of Conferences, 2017
Whale optimization algorithm (WOA) is a relatively novel intelligence optimization technique which has been shown to be competitive to other population-based algorithms.
Zhong Minghui, Long Wen
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

open access: yesFEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli   +8 more
wiley   +1 more source

渐开线齿轮反馈式稳健优化设计方法

open access: yesJixie chuandong, 2014
Aiming at the problems in the process of robust optimization design of involute gear,such as determining the dynamic load coefficient and multi-parameter nonlinear coupling,a method of dynamic load coefficient modified calculation is proposed.Through ...
周晓玲   +4 more
doaj  

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

open access: yesFEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake   +4 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

The Optimal Saving with Mixed Parameters

open access: yesProcedia Economics and Finance, 2014
This paper proposes two mixed models to study optimal saving in the presence of two types of risk: income risk and background risk. In the first model the income risk is a fuzzy number and the background risk is a random variable. In the second model the income risk is a random variable and the background risk is a fuzzy number.
Lucia Casademunt, Ana María   +1 more
openaire   +2 more sources

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

Interactive parameter optimization characteristics of hydrological models based on Large Language Models: a case study of the HBV and VIC models

open access: yesShui kexue jinzhan
Complex distributed hydrological models based on physical factors involve high computational costs,and it is difficult to apply conventional global optimization algorithms to these models because of the large number of model simulations required ...
Yehai TANG   +6 more
doaj   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

open access: yesFEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee   +3 more
wiley   +1 more source

Parameter Adaptive Manta Ray Foraging Optimization for Global Continuous Optimization Problems and Parameter Estimation of Solar Photovoltaic Models

open access: yesInternational Journal of Computational Intelligence Systems
The manta ray foraging optimization (MRFO) algorithm suffers from a fixed parameter $$ S $$ S , limiting its adaptability in balancing search capability and convergence speed during different optimization stages.
Zhentao Tang   +8 more
doaj   +1 more source

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