Results 31 to 40 of about 356,999 (268)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Driver’s Workspace Parameter Optimization

Механика машин, механизмов и материалов, 2011
In the article the issue concerning driver’s workspaces of existing vehicles and vehicles to be designed is being researched in order to increase the efficiently of human resources.
T.V. Kipen , V.S. Karotki , S.I. Kochetov , S.V. Kharytonchyk   +3 more
doaj  

Parameter Estimation for Modeling and Simulation of Multimodal Membrane Chromatography

Mathematical and Computational Applications
Protein chromatography, the process of separating desired proteins from other elements in a chemical solution, is used widely in the manufacturing of biotherapeutics.
Hannah Shead, Anastasia B. Wilson
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Sequential Parameter Optimization

, 2009
We provide a comprehensive, effective and very efficient methodology for the design and experimental analysis of algorithms. We rely on modern statistical techniques for tuning and understanding algorithms from an experimental perspective. Therefore, we make use of the sequential parameter optimization (SPO) method that has been successfully applied ...
openaire   +4 more sources

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Optimal Formation Trajectory-Planning Using Parameter Optimization Technique [PDF]

Journal of Astronomy and Space Sciences, 2004
Some methods have been presented to get optimal formation trajectories in the step of configuration or reconfiguration, which subject to constraints of collision avoidance and final configuration.
Hyung-Chul Lim, Hyo-Choong Bang, Kwan-Dong Park, Woo-Kyoung Lee   +3 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

RBF KERNEL OPTIMIZATION METHOD WITH PARTICLE SWARM OPTIMIZATION ON SVM USING THE ANALYSIS OF INPUT DATA’S MOVEMENT

Jurnal Ilmu Komputer dan Informasi, 2017
SVM (Support Vector Machine) with RBF (Radial Basis Function) kernel is a frequently used classification method because usually it provides an accurate results.
Rarasmaya Indraswari, Agus Zainal Arifin
doaj   +1 more source