Results 41 to 50 of about 356,999 (268)

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Parameter optimization for the unimon qubit

Physical Review Research
Inductively shunted superconducting qubits, such as the unimon qubit, combine high anharmonicity with protection from low-frequency charge noise, positioning them as promising candidates for the implementation of fault-tolerant superconducting quantum ...
Rostislav Duda, Eric Hyyppä, Olli Mukkula, Vasilii Vadimov, Mikko Möttönen   +4 more
doaj   +1 more source

An Improved Parameter Extraction Optimization Algorithm for RF Devices

Micromachines
This paper proposes an improved parameter extraction optimization algorithm for radio frequency (RF) devices. The algorithm integrates parameter classification and correction, gradient-based performance handling, bias-aware updates, and group-based ...
Shengsen Yang, Zihan Xu, Kun Ren
doaj   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source

A machine learning approach for online automated optimization of super-resolution optical microscopy

Nature Communications, 2018
Complex imaging systems like super-resolution microscopes currently require laborious parameter optimization before imaging. Here, the authors present an imaging optimization framework based on machine learning that performs simultaneous parameter ...
Audrey Durand, Theresa Wiesner, Marc-André Gardner, Louis-Émile Robitaille, Anthony Bilodeau, Christian Gagné, Paul De Koninck, Flavie Lavoie-Cardinal   +7 more
doaj   +1 more source

Accurate and reliable estimation of kinetic parameters for environmental engineering applications: A global, multi objective, Bayesian optimization approach

MethodsX, 2019
Accurate and reliable predictions of bacterial growth and metabolism from unstructured kinetic models are critical to the proper operation and design of engineered biological treatment and remediation systems. As such, parameter estimation has progressed
Derek C. Manheim, Russell L. Detwiler
doaj   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Seven-parameter PEMFC model optimization using an battlefield optimization algorithm

Electrochemistry Communications
Precise modeling of Proton Exchange Membrane Fuel Cells (PEMFCs) requires accurate identification of key parameters, which are often unavailable from manufacturers but crucial for predicting fuel cell performance.
Manish Kumar Singla, S.A. Muhammed Ali, Jyoti Gupta, Pradeep Jangir, Arpita, Ramesh Kumar, Reena Jangid, Mohammad Khishe   +7 more
doaj   +1 more source