Results 61 to 70 of about 314,179 (266)

Observations on the BayesianKeySearch with Applications to Simon and Simeck

IACR Transactions on Symmetric Cryptology
In CRYPTO 2019, Gohr pioneered the integration of machine learning with differential cryptanalysis, demonstrating that differential-neural distinguishers can outperform classical techniques in distinguishing attacks.
Zezhou Hou, Zhenzhen Bao, Jinyu Lu, Shaozhen Chen   +3 more
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Calculation of composite recovery time: a new pharmacodynamic parameter [PDF]

Journal of Antimicrobial Chemotherapy, 2002
A new pharmacodynamic parameter, the composite recovery time (CRT), is described and used to calculate species-specific MIC breakpoints. Moxifloxacin data were used for illustration. This required determination of MICs, kill curves and post-antibiotic sub-MIC effect values.
Fiona M, MacKenzie, Kathleen E, Milne, Ian M, Gould   +2 more
openaire   +2 more sources

Optimization of seminal extracellular vesicle isolation protocols for cancer biomarker analysis using proteomic profiling

Molecular Oncology, EarlyView.
This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan, Beatriz Martín‐Gracia, Eva Bassols‐Citores, Krizia Sagini, Maria K. Andersen, Tuula A. Nyman, May‐Britt Tessem, Morten B. Rye, Alicia Llorente   +8 more
wiley   +1 more source

Practical Recoverability and Numerical Identifiability of Kinetic Rate Constants from Noisy Time-Activity Curves in a Patient-Derived Renogram Model

Molecular Imaging
Close agreement between modeled and observed time-activity curves (TACs) does not necessarily imply accurate recovery of the underlying kinetic parameters.
Brandon Nguyen MS, Jackson Penning MD, MS, Zuzan Cayci MD, Farhad Jafari PhD   +3 more
doaj   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Item Parameter Recovery Using the Multidimensional Graded Response Model in R

Journal of Psychometric Research
The purpose of this study is to provide a step-by-step demonstration of item recovery for the Multidimensional Graded Response Model (MGRM) using R. For this purpose, an illustrative simulation setup was employed, including test lengths of 20 and 40 ...
Yeşim Beril Soğuksu, Ayşe Bilicioğlu Güneş, Hatice Gürdil   +2 more
doaj   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Impact of Spectral Coverage on Parameter Recovery in Blazar Modeling

The Astrophysical Journal
Understanding the impact of spectral coverage on parameter recovery is critical for accurate interpretation of blazar spectra. In this study, we examine how the data coverage influences the reliability of parameter estimation within the one-zone ...
N. Sahakyan, D. Bégué, P. Giommi, H. Dereli-Bégué, Asaf Pe’er   +4 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source