GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain +11 more
wiley +1 more source
The dynamic approach integrates Global Positioning System and K-band range-rate (KRR) observations to enable precise orbit determination (POD) and gravity field recovery.
Geng Gao +4 more
doaj +1 more source
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey +4 more
wiley +1 more source
A minimal cellulosome‐like system in Cellulosilyticum lentocellum
Cellulose‐degrading bacteria typically use cellulosomes, large multi‐enzyme complexes on a scaffold protein. In Cellulosilyticum lentocellum, we characterise a far smaller arrangement, a single scaffold bound to one cellulase through a single cohesin‐dockerin interaction.
John Allan +2 more
wiley +1 more source
Dominant performance parameter and technical limits of surfactants for oil displacement
In chemical flooding, emulsification and interfacial tension (IFT) reduction are crucial for enhanced oil recovery (EOR). However, the dominant performance parameter and technical limits of surfactants for oil displacement remain underexplored.
Yabing Guo +3 more
doaj +1 more source
Characterization of the key membrane protein cytochrome Cyc2 from Ghiorsea bivora
This study reports the first detailed biochemical analysis of Cyc2TAG1_1, a cytochrome protein involved in microbial iron oxidation. We produced and purified this enzyme in E. coli, then measured its iron‐oxidizing efficiency, and characterized its electrical and structural properties.
Josiane Azizi +6 more
wiley +1 more source
A current deviation control parameter tuning method to suppress subsequent commutation failure
If a subsequent commutation failure occurs in the line commutated converter-based high voltage direct current (LCC-HVDC) transmission system, it will have a seriously negative impact on the safe and stable operation of the AC-DC hybrid power grid. Aiming
LI Juan +4 more
doaj +1 more source
Simulation of low and high salinity water injection method to determine the optimum salinity
Investigating the enhanced oil recovery leads to optimal production, protection and reduction of lateral impacts. Low salinity water injection (LSWI) is one of the significantly improved oil recovery (IOR) techniques for changing the amount of ...
Seyed Mohammad Mehdi Nassabeh +2 more
doaj +1 more source
What are the consequences of ignoring cross-loadings in bifactor models? A simulation study assessing parameter recovery and sensitivity of goodness-of-fit indices. [PDF]
Ximénez C, Revuelta J, Castañeda R.
europepmc +1 more source
GBS‐MeDIP: A method for the simultaneous identification of genetic and epigenetic variants in tumors
GBS‐MeDIP combines DNA sequencing with enrichment of methylated DNA to profile genetic and epigenetic variation in the same reduced genomic fraction. Applied to gastric cancer and parathyroid tumors, it identifies sequence variants, copy number changes, and differentially methylated regions together, helping distinguish true epigenetic changes from ...
Fábio Pértille +6 more
wiley +1 more source

