Results 51 to 60 of about 675,051 (266)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Structural model updating of acceleration frequency response function based on Kriging method

工程科学学报, 2017
To improve the efficiency of frequency response function (FRF) model updating, the Kriging model is introduced into its optimization procedure, thus replacing the finite element model for iteration.
WANG Ju-tao, WANG Chun-jie, SONG Shun-guang   +2 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Enhanced brain tumor diagnosis using combined deep learning models and weight selection technique

Frontiers in Neuroinformatics
Brain tumor classification is a critical task in medical imaging, as accurate diagnosis directly influences treatment planning and patient outcomes.
Karim Gasmi, Najib Ben Aoun, Najib Ben Aoun, Khalaf Alsalem, Ibtihel Ben Ltaifa, Ibrahim Alrashdi, Lassaad Ben Ammar, Manel Mrabet, Abdulaziz Shehab   +8 more
doaj   +1 more source

Parameter Selection of a Support Vector Machine, Based on a Chaotic Particle Swarm Optimization Algorithm

Cybernetics and Information Technologies, 2015
This paper proposes a SVM (Support Vector Machine) parameter selection based on CPSO (Chaotic Particle Swarm Optimization), in order to determine the optimal parameters of the support vector machine quickly and efficiently.
Dong Huang, Jian Gao
doaj   +1 more source

Assessment of Selected Anthropometric Parameters Influence on Balance Parameters in Children

Medicina, 2020
Background and Objectives: Balance is the ability of an organism to maintain its position in space. Balance disorders in children can lead to injuries and limited physical activity. Balance maintenance changes throughout puberty as well as in response to external factors. The study aimed to evaluate the influence of anthropometric parameters on balance
Agnieszka Turon-Skrzypinska, Artur Uździcki, Tomasz Przybylski, Aleksandra Szylinska, Małgorzata Marchelek-Myśliwiec, Aleksandra Rył, Iwona Rotter   +6 more
openaire   +3 more sources

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Shaping the appearance of a long-range aircraft at the stage of developing a technical proposal

Вестник Дагестанского государственного технического университета: Технические науки, 2020
Objective. The process of designing a long-range aircraft, in particular at the preliminary design stage, involves comparing and analyzing a large number of design alternatives with specified performance criteria.
A. A. Gorbunov, A. D. Pripadchev
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Research on Optimization Parameter Selection Method for Hull Form Optimization

Machines
Hull form optimization is a key technical approach for developing energy-efficient ship hulls. However, selecting appropriate optimization parameters remains challenging.
Qiang Zheng, Baiwei Feng, Zuyuan Liu, Chengsheng Zhan, Xide Cheng   +4 more
doaj   +1 more source