Results 101 to 110 of about 5,756,257 (288)

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Finding excesses in model parameter space

European Physical Journal C: Particles and Fields
Simulation-based inference (SBI) makes it possible to infer the parameters of a model from high-dimensional low-level features of the observed events. In this work we show how this method can be used to establish the presence of a weak signal on top of ...
Kierthika Chathirathas, Torben Ferber, Felix Kahlhoefer, Alessandro Morandini   +3 more
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Steering in the parameter space of a mode-locked laser [PDF]

EPJ Web of Conferences
The specific control of individual mode-locking states in an ultrafast laser requires knowledge about its phase space. We use a Mamyshev oscillator as a model nonlinear system to present an all-electronic manipulation and steering of nonlinear states ...
Repgen P., Şura A., Makey G., Ilday F. Ö.   +3 more
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

LiDO: Exploring the Stable Plutino Parameter Space

The Planetary Science Journal
We present a publicly available, high-resolution, filled-parameter-space synthetic distribution of the plutinos, trans-Neptunian objects (TNOs) librating in the 3:2 mean-motion resonance with Neptune, with particular focus on the plutinos simultaneously ...
Samantha M. Lawler, Mark Comte, Rosemary E. Pike, Mike Alexandersen, Ying-Tung Chen, Cameron Collyer, Matthew Holman, J. J. Kavelaars, Lowell Peltier, Cameron Semenchuck   +9 more
doaj   +1 more source

Semantically Controlled Adaptive Equalisation in Reduced Dimensionality Parameter Space

Applied Sciences, 2016
Equalisation is one of the most commonly-used tools in sound production, allowing users to control the gains of different frequency components in an audio signal.
Spyridon Stasis, Ryan Stables, Jason Hockman   +2 more
doaj   +1 more source

On the parameter space of Böröczky configurations

, 2017
Böröczky configurations of lines have been recently considered in connection with the problem of the containment between symbolic and ordinary powers of ideals. Here we describe parameter families of Böröczky configurations of 13, 14, 16, 18 and 24 lines and investigate rational points of these parameter spaces.
Farnik, Łucja, Kabat, Jakub, Lampa-Baczyńska, Magdalena, Tutaj-Gasińska, Halszka   +3 more
openaire   +2 more sources

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source