Results 31 to 40 of about 14,986 (169)

Natural Killer Cells in Paediatric Soft Tissue Sarcomas: A Systematic Review

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Paediatric soft tissue sarcomas (pSTS) are a rare and heterogeneous group of malignant tumours arising in tissues of mesenchymal origin. The role of natural killer (NK) cells in pSTS remains poorly understood, with evidence fragmented across small preclinical studies and early‐phase clinical trials.
Raya Dean   +7 more
wiley   +1 more source

Parameter Identifiability for Nonlinear LPV Models

open access: yesInternational Journal of Applied Mathematics and Computer Science, 2022
Linear parameter varying (LPV) models are being increasingly used as a bridge between linear and nonlinear models. From a mathematical point of view, a large class of nonlinear models can be rewritten in LPV or quasi-LPV forms easing their analysis. From
Srinivasarengan Krishnan   +3 more
doaj   +1 more source

Forecasting the Dialysis Burden in Japan: Validation‐Based Projections of Prevalence and Incidence Through 2050

open access: yesTherapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin   +2 more
wiley   +1 more source

Dynamics of a Uniparametric Sixth-Order Family for Multiple Roots with Rational-Polynomial Weight Functions

open access: yesAxioms
In this study, we have performed a comprehensive dynamical assessment of a sixth-order parametric family of iterative methods for computing multiple roots of nonlinear equations.
Young Hee Geum
doaj   +1 more source

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Investigating the parameter space of evolutionary algorithms

open access: yesBioData Mining, 2018
Evolutionary computation (EC) has been widely applied to biological and biomedical data. The practice of EC involves the tuning of many parameters, such as population size, generation count, selection size, and crossover and mutation rates.
Moshe Sipper   +3 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Parameter space of baryogenesis in the νMSM

open access: yesJournal of High Energy Physics, 2019
The Standard Model accompanied with two right-handed neutrinos with masses below the weak scale can explain the observed baryon asymmetry of the Universe.
S. Eijima   +2 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

open access: yesFEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

On a Uniparametric Class of Sixth-Order Multiple-Root Finders Using Rational Weighting

open access: yesFractal and Fractional
This investigation provides a comprehensive analytical framework for the topological morphology and global convergence dynamics governing a specific family of sixth-order iterative schemes designed for nonlinear equations with multiple roots. By invoking
Young Hee Geum
doaj   +1 more source

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