Results 81 to 90 of about 8,464,096 (315)

Testing SUSY

, 2009
If SUSY provides a solution to the hierarchy problem then supersymmetric states should not be too heavy. This requirement is quantified by a fine tuning measure that provides a quantitative test of SUSY as a solution to the hierarchy problem. The measure
Allanach, Allanach, Allanach, Athron, Baer, Baer, Barate, Barbieri, Barbieri, Barbieri, Barbieri, Belanger, Carena, Cassel, Cassel, Chan, Chang, Chankowski, Chankowski, Chankowski, Ciafaloni, D.M. Ghilencea, Dermisek, Djouadi, Ellis, Ellis, Espinosa, Essig, Essig, Feng, Feng, G.G. Ross, Ghilencea, Ghilencea, Ghilencea, Ghilencea, Giudice, Hahn, Horton, Kane, Martin, Martin, Martin, Martin, Mayr, Mayr, Nilles, Romanino, S. Cassel, Schael   +49 more
core   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Parameter tuning in pointwise adaptation using a propagation approach

, 2009
This paper discusses the problem of adaptive estimation of a univariate object like the value of a regression function at a given point or a linear functional in a linear inverse problem.
Spokoiny, Vladimir, Vial, Céline
core   +4 more sources

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Neural Network-Based Parameter Tuning for Multi-Armed Bandit Algorithms [PDF]

ITM Web of Conferences
This paper presents a novel approach for dynamically tuning the exploration parameter in Multi-Armed Bandit (MAB) algorithms using Deep Q-Networks (DQN), focusing on enhancing performance in static and dynamic environments.
Shi Yuhan
doaj   +1 more source

Radiatively Generated Maximal Mixing Scenario for the Higgs Mass and the Least Fine Tuned Minimal Supersymmetric Standard Model

, 2006
We argue that given the experimental constraints on the Higgs mass the least fine tuned parameter space of minimal supersymmetric standard model is with negative stop masses squared at the grand unification scale.
Dermisek, Radovan, Kim, Hyung Do
core   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

K-essential Phantom Energy: Doomsday around the Corner? Revisited

, 2005
We generalize some of those results reported by Gonz\'{a}lez-D\'{i}az by further tuning the parameter ($\beta$) which is closely related to the canonical kinetic term in $k$-essence formalism.
A. Linde, A.H. Guth, C. Amendáriz-Picón, C. Amendáriz-Picón, C. Armendáriz-Picón, D.N. Spergel, H. Stefancic, J. Garriga, Kwang-Hua W. Chu, L. Kofman, L.P. Chimento, M. Malquarti, M. Malquarti, N. Kaloper, P.F. González-Díaz, R.R. Caldwell, S. Nesseris, S. Nojiri, S. Nojiri, S. Perlmutter, S. Perlmutter, T. Brunier, T. Chiba   +22 more
core   +3 more sources

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Parameter Tuning of Agent-Based Models: Metaheuristic Algorithms

Mathematics
When it comes to modelling complex systems using an agent-based approach, there is a problem of choosing the appropriate parameter optimisation technique.
Andrei I. Vlad, Alexei A. Romanyukha, Tatiana E. Sannikova   +2 more
doaj   +1 more source