Results 111 to 120 of about 29,740 (183)

Molecular Dynamics Analysis of Inhibitor Binding Interactions in the Vibrio cholerae Respiratory Complex NQR

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The sodium‐pumping ubiquinone oxidoreductase sodium pumping quinone reductase (NQR) is an important enzyme in the respiratory chain of multiple pathogenic gram‐negative bacteria. NQR has been proposed as a viable antibiotic target due to its importance in supporting energy‐consuming reactions and its absence in human cells.
Joseph. A. DePaolo‐Boisvert, Karina Tuz, David. D. L. Minh, Oscar X. Juarez   +3 more
wiley   +1 more source

Graph-Driven Micro-Expression Rendering with Emotionally Diverse Expressions for Lifelike Digital Humans. [PDF]

Biomimetics (Basel)
Fang L, Yang F, Lin Y, Zhang J, Whang M.
europepmc   +1 more source

A minimal physiologically‐based pharmacokinetic modeling platform to predict intratumor exposure and receptor occupancy of an anti‐LAG‐3 monoclonal antibody

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 460-473, March 2025.
Abstract In oncology drug development, measuring drug concentrations at the tumor site and at the targeted receptor remains an ongoing challenge. Positron emission tomography (PET)‐imaging is a promising noninvasive method to quantify intratumor exposure of a radiolabeled drug (biodistribution data) and target saturation by treatment doses in vivo ...
Robin Michelet, Klas Petersson, Marc C. Huisman, C. Willemien Menke‐van der Houven van Oordt, Iris H. C. Miedema, Andrea Thiele, Ghazal Montaseri, Alejandro Pérez‐Pitarch, David Busse   +8 more
wiley   +1 more source

PGRF: Physics-Guided Rectified Flow for Low-Light RAW Image Enhancement. [PDF]

J Imaging
Zeng J, Yang Q.
europepmc   +1 more source

Development of a physiologically‐based pharmacokinetic model for Ritonavir characterizing exposure and drug interaction potential at both acute and steady‐state conditions

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 523-539, March 2025.
Abstract Ritonavir (RTV) is a potent CYP3A inhibitor that is widely used as a pharmacokinetic (PK) enhancer to increase exposure to select protease inhibitors. However, as a strong and complex perpetrator of CYP3A interactions, RTV can also enhance the exposure of other co‐administered CYP3A substrates, potentially causing toxicity.
Lien Thi Ngo, Woojin Jung, Tham Thi Bui, Hwi‐yeol Yun, Jung‐woo Chae, Jeremiah D. Momper   +5 more
wiley   +1 more source

Modeling heterogeneous signaling dynamics of macrophages reveals principles of information transmission in stimulus responses. [PDF]

Nat Commun
Guo X, Adelaja A, Singh A, Wollman R, Hoffmann A.   +4 more
europepmc   +1 more source

A Tutorial on the Development of a Physiologically Inspired PKRO Model for Monoclonal Antibodies

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Modeling and simulations are indispensable tools to describe pharmacokinetics (PK) and pharmacodynamics to support monoclonal antibody (mAb) development. The linear PK of mAbs is commonly described by a 2‐compartment PK model, while the nonlinear PK often observed at low doses is described by target mediated drug disposition (TMDD) models ...
Georgi I. Kapitanov, David Flowers, Diana H. Marcantonio, Timothy R. Lezon, Josh F. Apgar, Fei Hua   +5 more
wiley   +1 more source

Mathematical modeling reveals ferritin as the strongest cellular driver of dietary iron transfer block in enterocytes. [PDF]

PLoS Comput Biol
Masison J, Mendes P.
europepmc   +1 more source

Evaluation of the PK/PD Changes on MASLD‐Related Population—An Example From Simultaneous Acetaminophen Parent‐Metabolite PBPK/PD Modeling

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Patients with metabolic dysfunction‐associated steatotic liver disease (MASLD) may exhibit altered pharmacokinetics (PK) and pharmacodynamics (PD) of drugs compared with healthy populations. However, no physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD) model has been specifically developed for MASLD.
Shanshan Zhao, Lan Zhang
wiley   +1 more source

CrossDF: improving cross-domain deepfake detection with deep information decomposition. [PDF]

Front Big Data
Yang S, Guo H, Hu S, Zhu B, Fu Y, Lyu S, Wu X, Wang X.   +7 more
europepmc   +1 more source