Results 121 to 130 of about 29,740 (183)

A Quantitative Systems Pharmacology (QSP) Model of Acute Hepatitis B Virus Infection: Mechanistic Insights and Foundations for Future Extensions

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Chronic hepatitis B virus (HBV) infection remains a significant global health challenge. While the dynamic interplay between viral replication and host immune responses determines infection outcomes, the mechanisms driving the resolution of acute infection versus the emergence of chronicity remain incompletely understood.
Clémence Boivin‐Champeaux, Stephan Schmidt, Scott Balsitis, Francine Johansson Azeredo, Justin S. Feigelman   +4 more
wiley   +1 more source

Approximating the ideal observer for joint signal detection and estimation tasks by the use of Markov-Chain Monte Carlo with generative adversarial networks. [PDF]

J Med Imaging (Bellingham)
Li D, Li K, Zhou W, Anastasio MA.
europepmc   +1 more source

Improving convection‐permitting all‐sky infrared radiance ensemble data assimilation through mitigating deleterious non‐Gaussian artifacts

Quarterly Journal of the Royal Meteorological Society, EarlyView.
Ensemble Kalman filters (EnKFs) with quality control (QC) are commonly used in the data assimilation (DA) of all‐sky satellite‐sensed infrared radiance (IR) observations. However, the statistical assumptions underlying EnKFs and QC are violated in such DA.
Man‐Yau Chan
wiley   +1 more source

A multi-omics analysis unveils functional and regulatory links between hydroxybenzene and aromatic amino acid metabolism in <i>Candida albicans</i>. [PDF]

mSystems
Garbe E, Schäuble S, Böttcher B, Jesse R, Driesch D, van Wilijck L, Elshafee O, Schille TB, Hube B, Panagiotou G, Vylkova S.   +10 more
europepmc   +1 more source

Physically consistent mesoscale model evaluation in complex terrain

Quarterly Journal of the Royal Meteorological Society, EarlyView.
This study introduces a novel approach for evaluating mesoscale atmospheric models in complex terrain by selecting physically consistent grid points and applying height‐based corrections. The method corrects for sensor height and terrain elevation differences between model and observations using a time‐varying lapse rate.
Gaspard Simonet, Mathias W. Rotach, Manuela Lehner   +2 more
wiley   +1 more source

From Linear Geometry to Nonlinear and Information-Geometric Settings in Test Theory: Bregman Projections as a Unifying Framework. [PDF]

Educ Psychol Meas
Zumbo BD.
europepmc   +1 more source

Ensemble Kalman filter in latent space using a variational autoencoder pair

Quarterly Journal of the Royal Meteorological Society, EarlyView.
The use of the ensemble Kalman filter (EnKF) in strongly nonlinear or constrained atmospheric, oceanographic, or sea‐ice models can be challenging. Applying the EnKF in the latent space of a variational autoencoder (VAE) ensures that the ensemble members satisfy the balances and constraints present in the model.
Ivo Pasmans, Yumeng Chen, Tobias Sebastian Finn, Marc Bocquet, Alberto Carrassi   +4 more
wiley   +1 more source

Quantitative modeling of rod outer segment phagocytosis and recycling. [PDF]

Sci Rep
Kiel C, Foss AJE.
europepmc   +1 more source

Simulating Quantum State Transfer Between Distributed Devices Using Noisy Interconnects

Advanced Quantum Technologies, EarlyView.
Noisy connections challenge future networked quantum computers. This work presents a practical method to address this by simulating an ideal state transfer over noisy interconnects. The approach reduces the high sampling cost of previous methods, an advantage that improves as interconnect quality gets better.
Marvin Bechtold, Johanna Barzen, Frank Leymann, Alexander Mandl   +3 more
wiley   +1 more source

MexR and NalD are pyocyanin-responsive transcriptional repressors of the efflux pump MexAB-OprM in Pseudomonas aeruginosa. [PDF]

Nucleic Acids Res
Wu C, Wang M, Xiao Y, Zhao S, Jiang X, Zhang K, Wang H, Dong H, Xu S, Su T, Gu L.   +10 more
europepmc   +1 more source