Results 61 to 70 of about 4,273,523 (249)
Comparative Economic Research, 2018 The preliminary results of the development of the initial theoretical, methodological and applied methodological provisions for the study of the profile of a modern Ukrainian manager are presented in the context of predicting its transformation in the ...
Beata Glinkowska +1 more
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
, 1993 This note is a brief survey and a discussion of recent ideas and open problems in the understanding of an important aspect of Type Theory: how terms may depend on types. This problem is at the core of the distinction between “ad hoc” and proper polymorphism and inspired the large amount of work on “parametricity”.
openaire +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
SOME STATISTICAL DISTRIBUTIONS, WHICH DESCRIBE THE NANOTOPOGRAPHY OF TECHNICAL SURFACES
Физико-химические аспекты изучения кластеров, наноструктур и наноматериалов, 2020 The nanotopography of engineering surfaces of machine parts made of high alloy heat-treated steel and electric silver after finishing mechanical treatment was studied.
V.V. Izmailov, M.V. Novoselova
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Stochastic Generator of a New Family of Lifetime Distributions with Illustration
Revstat Statistical JournalIn this article, a new family of lifetime distributions is introduced to help researchers model different types of data sets. Furthermore, the maximum likelihood method was used in estimating the model's parameters.
Amjad Al-Nasser, Ahmad Hanandeh
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Second international workshop on particle physics and the early universe (COSMO-98), 1999 The discussion of cosmological parameters used to be a source of embarrassment to cosmologists. Today, measurements of the cosmological parameters are leading the way into the era of precision cosmology. The CMB temperature is measured to four significant figures, T_0=2.7277+/-0.002 K; the Hubble constant is now determined with a reliable error ...
openaire +2 more sources
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source