Results 121 to 130 of about 607,854 (297)
Repurposing FDA‐Approved Drugs to Inhibit Fungal PPTases for Broad‐Spectrum Synergy
Advanced Science, EarlyView.Fungal secondary metabolites serve as crucial virulence effectors; however, the potential of their biosynthetic pathways as antifungal targets remains inadequately comprehended. Repurposed FDA‐approved drugs inhibit fungal PPTase (essential for secondary metabolism) in vivo.
Zili Song +7 more
wiley +1 more source
The shifting boxplot. A boxplot based on essential summary statistics around the mean.
International Journal of Psychological Research, 2010 Boxplots are a useful and widely used graphical technique to explore data in order to better understand the information we are working with. Boxplots display the first, second and third quartile as well as the interquartile range and outliers of a data ...
Fernando Marmolejo-Ramos, Tian Siva Tian
doaj +1 more source
Evaluation of the type I error rate when using parametric bootstrap analysis of a cluster randomized controlled trial with binary outcomes and a small number of clusters. [PDF]
Comput Methods Programs Biomed, 2022 Golzarri-Arroyo L +8 more
europepmc +1 more source
Advanced Science, EarlyView.The effect of ligand reactivity and carrier mechanics on thiol‐mediated uptake was investigated at the single‐molecule/particle level. The interaction kinetics of LA and AspA with membrane thiols were quantified; AspA is more efficient due to the higher binding affinity, greater binding stability, and more double‐disulfide binding, as well as greater ...
Zhuang Zhang +7 more
wiley +1 more source
A semi-parametric bootstrap-based best linear unbiased estimator of location under symmetry. [PDF]
Commun Stat Simul Comput, 2022 Hutson AD.
europepmc +1 more source
Advanced Science, EarlyView.The protein aggregates and gene expression in the middle temporal gyrus (MTG) and somatosensory cortex (SOM) of the postmortem brains of 13 Alzheimer's disease patients were studied in detail, revealing that small hyperphosphorylated tau aggregates increase with Braak stage driven by microglial inflammation.
Elizabeth A. English +9 more
wiley +1 more source
Towards a Compositional Framework for Describing Human Phenotypes
Advanced Science, EarlyView.The Phenotype Assembly Method (PhenoAM) decomposes phenotype variables into measurable Features and typed Qualifiers, enabling standardized, machine‐readable Phenome Data Elements (PhenoDEs) that preserve measurement context. Applied in the International Human Phenome Project (IHPP), the framework yields 58 371 PhenoDEs and supports component‐level ...
Wanting Hu +11 more
wiley +1 more source
MANOVA for Nested Designs with Unequal Cell Sizes and Unequal Cell Covariance Matrices
Journal of Applied Mathematics, 2014 We propose and study parametric bootstrap (PB) tests for heteroscedastic two-factor MANOVA with nested designs. For the problem of testing “main effects” of both factors, we develop a flexible test based on a parametric bootstrap approach. The PB test is
Li-Wen Xu
doaj +1 more source
Advanced Science, EarlyView.Grounded in real biological RNA‐seq data, the framework benchmarks ten differential transcript usage (DTU) methods across short‐read bulk, long‐read bulk, long‐read single‐cell, and long‐read spatial transcriptomics. By integrating reference transcript sets with ranked DTU results, the Transcript Set Enrichment Score (TSES) identifies data‐type ...
Chenxing Zhang +6 more
wiley +1 more source
The information matrix test with bootstrap-based covariance matrix estimation. [PDF]
We propose an information matrix test in which the covariance matrix of the vector of indicators is estimated using the parametric bootstrap. Monte Carlo results and heuristic arguments show that its small sample performance is comparable with that of ...
Hoorelbeke, Dirk, Dhaene, Geert
core +2 more sources