Results 51 to 60 of about 65,965 (261)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Spatiotemporal order and parametric instabilities from first-principles

npj Quantum Materials
Shaping crystal structure with light is an enduring goal of physics and materials engineering. Here we present calculations in candidate materials selected by symmetry that allow light-induced spatiotemporal parametric instabilities.
Daniel Kaplan, Pavel A. Volkov, Jennifer Coulter, Shiwei Zhang, Premala Chandra   +4 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Parametric and self-excited oscillations under nonlinear parametric action and lag in elasticity

St. Petersburg Polytechnical University Journal: Physics and Mathematics
The interaction of parametric oscillations and self-oscillations under nonlinear parametric excitation and delay in elasticity is considered. To solve the differential equations of the system motion, the direct linearization method was used and equations
Alifov Alishir
doaj   +1 more source

Proposals for the Multiparametric Design Application in Electrical Mechanical Engineering [PDF]

Problems of the Regional Energetics
The aim of the work is to obtain practical results for the electrical machines multiparametric de-sign application, to conduct a comparative analysis of the parametric and multiparametric design results of a turbogenerator and its elements when the load ...
Shevchenko V.V., Minko A.N., Stoychev V.T.   +2 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

The influence of nonlinear parametric excitation on the interaction of forced, parametric and self-oscillations

St. Petersburg Polytechnical University Journal: Physics and Mathematics
In order to reveal the effect of nonlinear (cubic) parametric excitation (NPE) on the interaction of forced, parametric, and self-oscillation with a limited-power energy source, a widely used computed model of a self-oscillating system receiving energy ...
Alifov Alishir
doaj   +1 more source

Dynamic Display of Changing Posterior in Bayesian Survival Analysis: The Software

Journal of Statistical Software, 1999
We consider the problem of estimating an unknown distribution function in the presence of censoring under the conditions that a parametric model is believed to hold approximately.
Hani J. Doss, Balasubramanian Narasimhan
doaj   +1 more source