Results 31 to 40 of about 129,549 (262)

Bifurcations of backbone curves for systems of coupled nonlinear two mass oscillator [PDF]

, 2014
This paper considers the dynamic response of coupled, forced and lightly damped nonlinear oscillators with two degree-of-freedom. For these systems, backbone curves define the resonant peaks in the frequency-displacement plane and give valuable ...
Neild, S.A., Cammarano, A., Hill, T. L., Wagg, D. J., Neild, S. A., Hill, T.L., Wagg, D.J.   +6 more
core   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Fitting Constrained Continuous Spline Curves. [PDF]

, 2003
Fitting a curve through a set of planar data which represents a positive quantity requires that the curve stays above the horizontal axis, The more general problem of designing parametric and non-parametric curves which do not cross the given constraint
Ong, B. H., Kong, V.P.
core  

On-line segmentation of freehand sketches by knowledge-based nonlinear thresholding operations

, 2001
This paper describes an on-line procedure for segmenting freehand sketches into 2D primitives and smooth curves by knowledge-based nonlinear thresholding operations. Drawing position, direction, speed and acceleration information is used for establishing
Wright, David, Qin, SF, Qin, Sheng-feng, Wright, DK, Jordanov, IN, Qin, Shengfeng, Jordanov, Ivan   +6 more
core   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Low level direct interpolation for parametric curves [PDF]

, 2020
This article presents an algorithm for the direct interpolation of parametric planar curves C(u) with a CNC machine. It expresses parametric planar curves as sequences of machine tool axes discrete movements of BLU size.
Martínez, Adriana, Ruiz, Oscar, Rendón, Elizabeth   +2 more
core  

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Real parametrization of algebraic curves [PDF]

, 1998
There are various algorithms known for deciding the parametrizability (rationality) of a plane algebraic curve, and if the curve is rational, actually computing a parametrization. Optimality criteria such as low degrees in the parametrization or low degree field extensions are met by some parametrization algorithms.
J. Rafael Sendra, Franz Winkler 0001
openaire   +1 more source