Results 61 to 70 of about 430,378 (285)
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Constant-Ratio Blended Models of Curves and Surfaces in Euclidean 3-Space
Journal of MathematicsWe consider a simple blending method for parametric curves and surfaces. The described blending method offers a systematic approach to creating smooth transitions between parametric curves and surfaces while maintaining Cn-continuity.
B. Bulca Sokur
doaj +1 more source
A Bayesian non-parametric mixed-effects model of microbial growth curves.
PLoS Computational Biology, 2020 Substantive changes in gene expression, metabolism, and the proteome are manifested in overall changes in microbial population growth. Quantifying how microbes grow is therefore fundamental to areas such as genetics, bioengineering, and food safety ...
Peter D Tonner +5 more
doaj +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Symbolic parametrization of curves
Journal of Symbolic Computation, 1991 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Sendra, J. Rafael, Winkler, Franz
openaire +1 more source
Parametrizations of elliptic curves by Shimura curves and by classical modular curves [PDF]
Proceedings of the National Academy of Sciences, 1997 Fix an isogeny class 𝒜 of semistable elliptic curves over Q. The elements of 𝒜 have a common conductor N , which is a square-free positive integer. Let D be a divisor of N which is the product of an even number of primes—i.e., the discriminant of an indefinite ...
Ribet, Kenneth A., Takahashi, Shuzo
openaire +3 more sources
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Computer Assisted Methods in Engineering and Science, 2023 This paper concerns modelling of surfaces resulting from measurements or from digital simulation of surfaces e.g., tooth flanks, based on the theory of gearing, with intentionally introduced modification usually defined in discrete form.
Andrzej Kawalec
doaj
Certain Algorithms for Modeling Uncertain Data Using Fuzzy Tensor Product Bézier Surfaces
Mathematics, 2018 Real data and measures are usually uncertain and cannot be satisfactorily described by accurate real numbers. The imprecision and vagueness should be modeled and represented in data using the concept of fuzzy numbers.
Musavarah Sarwar, Muhammad Akram
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source