Results 131 to 140 of about 1,068,788 (332)

Parametric Design of Hip Implant With Gradient Porous Structure. [PDF]

Front Bioeng Biotechnol, 2022
Gao X, Zhao Y, Wang M, Liu Z, Liu C.
europepmc   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Helicopter Main Rotor Blade Parametric Design for a Preliminary Aerodynamic Analysis Supported by CFD or Panel Method. [PDF]

Materials (Basel), 2022
Kocjan J, Kachel S, Rogólski R.
europepmc   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Active Strategies Based on Parametric Design for Applying Shading Structures

Applied Sciences
This study aimed to increase the energy independence of buildings by utilizing solar energy to produce renewable energy. The subject of this study was a shading structure installed in an outdoor space to provide solar energy. Solar panels were applied to
Ho-Soon Choi
doaj   +1 more source

Parametric Design Studies of Mass-Related Global Warming Potential and Construction Costs of FRP-Reinforced Concrete Infrastructure. [PDF]

Polymers (Basel), 2022
Preinstorfer P, Huber T, Reichenbach S, Lees JM, Kromoser B.   +4 more
europepmc   +1 more source

THE IMPLEMENTATION OF PARAMETRIC DESIGN PRACTICE IN ARCHITECTURE TEACHING – HOW IT CAN BE IMPLEMENTED IN INDONESIA?

, 2022
Wendy Sunarya, Heru Subiyantoro, Yusvika Ratri Harmunisa, Rizka Tiara Maharani   +3 more
openalex   +2 more sources

Passive retention/expulsion methods for subcritical storage of cryogens [PDF]

Design and parametric analysis of passive retention/expulsion system for subcritically stored cryogens during low-

core   +1 more source

Parametric tools in architecture: a comparative study [PDF]

, 2012
Parametric tools have recently increased in eminence in architectural practice with several claims made about their potential as a creative design iteration tool to enhance design decision making and problem solving.
Hanna, Raid
core  

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source