Results 111 to 120 of about 9,961,576 (291)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Landscape Design asArt: An Experimental Methodology with the Use of Neurographic Art and Metaball Geometry

International Journal of Built Environment and Sustainability
With the use of new technological solutions, non-Euclidean forms can be created in various software platforms and can be produced or fabricated in order to be parts of real world design works.
Asli Agirbas, Roza Sabyrova, Tarik Emre Kirhalli   +2 more
doaj   +1 more source

Finite Element Parametric Design of Hallux Valgus Orthosis Based on Orthogonal Analysis. [PDF]

Orthop Surg, 2023
Tang Z, Wu Y, Bao W, Chen X, Zhang D, Korotkov AN, Zheng W, Gu S.   +7 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Analytic Solutions for Volume, Mass, Center of Gravity, and Inertia of Wing Segments and Rotors of Constant Density

Aerospace
In the preliminary design of aircraft lifting surfaces, accurate mass and inertia properties can be difficult to obtain. Typically, such methods as computer-aided design or statistical processes are used to determine these properties.
Benjamin C. Moulton, Douglas F. Hunsaker
doaj   +1 more source

DFMA-oriented modular and parametric design and secondary splitting of vertical PC components. [PDF]

Sci Rep, 2023
Dong D, Zou Y, Pan H, Zhou G, Feng Y, Tang Y.   +5 more
europepmc   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Parametric Algorithms Used as a Design Tool for Auxetic Structure Development

Proceedings
This study delves into the realms of Parametric Design and Auxetic Structures, focusing on structures exhibiting unconventional behavior, i.e., those that have a mechanical function inverse to the conventional one and expand when subjected to an external
Ricardo Augusto Palmieri, Silvia Titotto
doaj   +1 more source

Parametric Design of Hip Implant With Gradient Porous Structure. [PDF]

Front Bioeng Biotechnol, 2022
Gao X, Zhao Y, Wang M, Liu Z, Liu C.
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source