Results 91 to 100 of about 354,890 (263)
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
BioResources, 2023 Structural systems built from raw bamboo have been used for years due to its highly renewable characteristics, versatility, and abundance in various countries, e.g., China, Indonesia, all over South America, and especially Brazil. It is also considered a
Bruna A. Gaffuri +5 more
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Parametric Design of Hip Implant With Gradient Porous Structure. [PDF]
Front Bioeng Biotechnol, 2022 Gao X, Zhao Y, Wang M, Liu Z, Liu C.
europepmc +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Helicopter Main Rotor Blade Parametric Design for a Preliminary Aerodynamic Analysis Supported by CFD or Panel Method. [PDF]
Materials (Basel), 2022 Kocjan J, Kachel S, Rogólski R.
europepmc +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Active Strategies Based on Parametric Design for Applying Shading Structures
Applied SciencesThis study aimed to increase the energy independence of buildings by utilizing solar energy to produce renewable energy. The subject of this study was a shading structure installed in an outdoor space to provide solar energy. Solar panels were applied to
Ho-Soon Choi
doaj +1 more source
Parametric Design Studies of Mass-Related Global Warming Potential and Construction Costs of FRP-Reinforced Concrete Infrastructure. [PDF]
Polymers (Basel), 2022 Preinstorfer P +4 more
europepmc +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Jixie chuandong, 2008 The strategy of parametric design and the choice of development tools are introduced,and the output plate of the planetary bevel-type continuously variable transmission（CVT）as example,the process of parametric design system development of the CVT is ...
周春国, 程伟华, 刘凯
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