Results 81 to 90 of about 354,890 (263)

Parametric Design and Prototyping of a Low-Power Planar Biped Robot. [PDF]

Biomimetics (Basel), 2023
Şafak KK, Baturalp TB, Bozkurt S.
europepmc   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Landscape Design asArt: An Experimental Methodology with the Use of Neurographic Art and Metaball Geometry

International Journal of Built Environment and Sustainability
With the use of new technological solutions, non-Euclidean forms can be created in various software platforms and can be produced or fabricated in order to be parts of real world design works.
Asli Agirbas, Roza Sabyrova, Tarik Emre Kirhalli   +2 more
doaj   +1 more source

Learning Parametric Designing [PDF]

, 2012
Parametric designing, its instruments, and techniques move architectural design education towards novel avenues of deep learning. Akin to learning and working environments of engineering and manufacturing, it offers similar advantages for architects. Yet it is not as simple as using another tool; parametric designing fundamentally shifts the engagement
openaire   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Parametric Design of a 3D-Printed Removable Common-Mode Trap for Magnetic Resonance Imaging. [PDF]

IEEE MTT-S Int Microw Biomed Conf, 2023
Narongrit FW, Ramesh TV, Rispoli JV.
europepmc   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Finite Element Parametric Design of Hallux Valgus Orthosis Based on Orthogonal Analysis. [PDF]

Orthop Surg, 2023
Tang Z, Wu Y, Bao W, Chen X, Zhang D, Korotkov AN, Zheng W, Gu S.   +7 more
europepmc   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

DFMA-oriented modular and parametric design and secondary splitting of vertical PC components. [PDF]

Sci Rep, 2023
Dong D, Zou Y, Pan H, Zhou G, Feng Y, Tang Y.   +5 more
europepmc   +1 more source