Results 71 to 80 of about 9,961,576 (291)
Enhancing parametric design through non-manifold topology [PDF]
, 2017 © 2017 Elsevier Ltd This paper aims to build a theoretical foundation for parametric design thinking by exploring its cognitive roots, unfolding its basic tenets, expanding its definition through new concepts, and exemplifying its potential through a use-
Peter Theobald +9 more
core +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Application of Freeform Surface to the Parametric Design of Plate Sheet Structure
Chemical Engineering Transactions, 2018 This paper constructs a small-scale, lightweight structure with complex freeform surfaces via parametric design. First, the method of freeform surface modelling and parametric design were introduced, and combined into the parametric design aided freeform
Wei Zhang +3 more
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Multi-Objective Optimizing Curvilinear Steel Bar Structures of Hyperbolic Paraboloid Canopy Roofs
Buildings, 2020 The paper concerns shaping curvilinear steel bar structures that are hyperbolic paraboloid canopy roofs by means of parametric design software Rhinoceros/Grasshopper and Karamba 3D.
Jolanta Dzwierzynska
doaj +1 more source
A Schema for Capturing and Comparing Parametric Spatial Data
, 2013 In this paper, the authors consider the problem of architectural spatial performance indicators for assessing computer generated design, where identification and analysis of meaningful and relevant spatial qualities is the target of assessment. The paper
Coorey, BP +3 more
core
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Parametric Design in Timber Gridshell Tectonics
SHS Web of Conferences, 2018 This paper begins with a simple proposition: rather than mimicking the geometric structures found in nature, perhaps the most effective modes of sustainable fabrication can be found throughunderstanding the nature of materials themselves.
Ismailiyah Al Athas Syarifah
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source