Results 91 to 100 of about 3,069,996 (290)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

The factors of spontaneous parametric down conversion process in BiB3O6 crystal with a broadband pump

open access: yes, 2013
We investigate the spontaneous parametric down-conversion (SPDC) process in biaxial nonlinear crystal BiB3O6 (BIBO) with a broadband pump. Under the type I and type II phase-matching conditions, we numerically calculate the influencing factors on SPDC ...
Zhao, Wei   +4 more
core   +1 more source

Anti-Zeno effect in parametric down-conversion [PDF]

open access: yes, 1998
© 1998 The American Physical Society. We wish to thank Professor G. García-Alcaine for a careful reading of the manuscript.Two examples are presented where the observation of the emission in parametric down-conversion leads to its enhancement instead of ...
Luis Aina, Alfredo   +1 more
core   +1 more source

Interference fringes in a nonlinear Michelson interferometer based on spontaneous parametric down-conversion

open access: yes, 2021
Quantum nonlinear interferometers (QNIs) can measure the infrared physical quantities of a sample by detecting visible photons. A QNI with Michelson geometry based on the spontaneous parametric down-conversion in a second-order nonlinear crystal is ...
Liu-Long Wang (11424799)   +9 more
core   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

open access: yesMolecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens   +6 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

Photon correlations in type-I optical parametric down-conversion

open access: yes, 2000
We develop a quantum theory for photon-pair correlations in type-I spontaneous parametric down-conversion, including crystal dispersion. We obtain different amplitudes for the correlations of degenerate (identical frequencies) and non-degenerate ...
Sarkar, S; id_orcid   +2 more
core   +3 more sources

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

Absolute measurement of detector quantum efficiency using optical parametric down-conversion pumped by femtosecond laser pulses

open access: yes, 2002
Absolute measurement of detector quantum efficiency using optical parametric down-conversion has been extensively studied for the case of a continuous wave pump.
Lu SL,Chinese Acad Sci,Inst Semicond,Natl Lab Superlattices & Microstruct,POB 912,Beijing 100083,Peoples R China.   +5 more
core  

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