Results 71 to 80 of about 702,666 (251)

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Brand gender and cross-gender extensions. [PDF]

Afin de se développer et de générer des profits, la plupart des marques de luxe utilisent les stratégies d’extension de marque, c'est-à-dire qu’elles essaient de s’introduire dans de nouvelles catégories de produits.
Nyeck, Simon, Veg, Nathalie
core  

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Ultra-broadband optical parametric amplifiers

, 2004
Parametric interactions in non-linear crystals allow to generate ultrabroadband tunable pulses. In this paper we review work done in the visible and present recent extensions to the near-infrared and UV spectral ranges, by means of optical parametric ...
Cerullo G, S, De Silvestri, Manzoni C, ZavelaniRossi M, Polli D   +5 more
core  

Oxford Common File Layout - Extensions

, 2022
First release of contributed extensions.
bcail, Peter Winckles, Rosalyn Metz, neilsjefferies, Dan Granville, michael-lts, Andrew Woods, Simeon Warner   +7 more
core   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Qiskit-Extensions/circuit-knitting-toolbox: Circuit Knitting Toolbox 0.7.0

<h2>What's Changed</h2> <ul> <li>Update target branch for docs build and mergify by @caleb-johnson in https://github.com/Qiskit-Extensions/circuit-knitting-toolbox/pull/493</li> <li>Add support for Python 3.12 by ...
Saasha Joshi, dharmash, Ibrahim Shehzad, Paul Schweigert, Das Pemmaraju, Hitomi Takahashi, Owen Lockwood, Eric Arellano, Caleb Johnson, seetharamiseelam, Jen Glick, Kevin J. Sung, Jim Garrison, weiT1993   +13 more
core   +1 more source

Quantum limit cycles with continuous symmetries from coherent parametric driving: Exact solutions and many-body extensions

Physical Review Research
There is widespread interest in many-body quantum systems that exhibit limit-cycle or time-crystalline behavior. An ideal quantum limit cycle would be realized using fully coherent driving (to minimize noise) and also have a continuous internal symmetry (
Sihan Chen, Aashish A. Clerk
doaj   +1 more source