Results 61 to 70 of about 702,666 (251)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

-Boundedness of Marcinkiewicz Integrals along Surfaces with Variable Kernels: Another Sufficient Condition

Journal of Inequalities and Applications, 2007
We give the estimates for the Marcinkiewicz integral with rough variable kernels associated to surfaces. More precisely, we give some other sufficient conditions which are different from the conditions known before to warrant that the -boundedness ...
Yabuta Kôzô, Xue Qingying
doaj  

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Frequency conversion based on three-wave parametric solitons [PDF]

, 2010
Parametric three-wave mixing in quadratic nonlinear crystals provides a versatile means of achieving widely tunable frequency conversion of laser light, thus permitting a substantial extension of the wavelength coverage of laser sources across broad ...
Degasperis, Antonio, A. DE GASPERIS, de Angelis, Costantino, Wabnitz, Stefan, DE ANGELIS C, Lombardo, Sara, S. LOMBARDO, CONFORTI M, DE GASPERIS, Antonio, Baronio, Fabio, Matteo Conforti, BARONIO F, Stefan Wabnitz, Sara Lombardo, Costantino De, Conforti, Matteo, Fabio Baronio, Antonio Degasperis   +17 more
core   +1 more source

Smooth Sigmoid Surrogate (SSS): An Alternative to Greedy Search in Decision Trees

Mathematics
Greedy search (GS) or exhaustive search plays a crucial role in decision trees and their various extensions. We introduce an alternative splitting method called smooth sigmoid surrogate (SSS) in which the indicator threshold function used in GS is ...
Xiaogang Su, George Ekow Quaye, Yishu Wei, Joseph Kang, Lei Liu, Qiong Yang, Juanjuan Fan, Richard A. Levine   +7 more
doaj   +1 more source

Robust test method for time-course microarray experiments

BMC Bioinformatics, 2010
Background In a time-course microarray experiment, the expression level for each gene is observed across a number of time-points in order to characterize the temporal trajectories of the gene-expression profiles.
George Stephen L, Owzar Kouros, Sohn Insuk, Kim Sujong, Jung Sin-Ho   +4 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Extensions of Modified DEA [PDF]

Andersen and Petersen (1993) presented an extension of the basic DEA methodology, called modified DEA, which has the desirable feature of ranking not only the inefficient DMUs, but the e ficient ones as well.
Mei Xue, Patrick T. Harker
core  

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source