Results 71 to 80 of about 1,368,395 (298)

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Syntax for free: representing syntax with binding using parametricity [PDF]

, 2009
We show that, in a parametric model of polymorphism, the type ∀ α. ((α → α) → α) → (α → α → α) → α is isomorphic to closed de Bruijn terms. That is, the type of closed higher-order abstract syntax terms is isomorphic to a concrete representation.
B.E. Aydemir, D.R. Licata, E. Moggi, F. Pfenning, G. Washburn, G.D. Plotkin, J. Carette, J. Despeyroux, M. Rhiger, N.G. Bruijn de, R. Harper, T. Coquand   +11 more
core   +2 more sources

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Inference for copula modeling of discrete data: a cautionary tale and some facts

Dependence Modeling, 2017
In this note, we elucidate some of the mathematical, statistical and epistemological issues involved in using copulas to model discrete data. We contrast the possible use of (nonparametric) copula methods versus the problematic use of parametric copula ...
Faugeras Olivier P.
doaj   +1 more source

An analysis of the cost of hyper-parameter selection via split-sample validation, with applications to penalized regression

, 2019
In the regression setting, given a set of hyper-parameters, a model-estimation procedure constructs a model from training data. The optimal hyper-parameters that minimize generalization error of the model are usually unknown.
Feng, Jean, Simon, Noah
core   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Utilizing Artificial Neural Networks for Geometric Bone Model Reconstruction in Mandibular Prognathism Patients

Mathematics
Patient-specific 3D models of the human mandible are finding increasing utility in medical fields such as oral and maxillofacial surgery, orthodontics, dentistry, and forensic sciences.
Jelena Mitić, Nikola Vitković, Miroslav Trajanović, Filip Górski, Ancuţa Păcurar, Cristina Borzan, Emilia Sabău, Răzvan Păcurar   +7 more
doaj   +1 more source

Kneadings, Symbolic Dynamics and Painting Lorenz Chaos. A Tutorial

, 2012
A new computational technique based on the symbolic description utilizing kneading invariants is proposed and verified for explorations of dynamical and parametric chaos in a few exemplary systems with the Lorenz attractor.
Abad A., Afraimovich V., Afraimovich V., ANDREY SHILNIKOV, Barrio R., Barrio R., Bykov V. V., Glendinning P., Gonchenko S. V., Hubner U., LEONID SHILNIKOV, Malkin M., ROBERTO BARRIO, Roshchin N., Rychlic M., Shilnikov A., Shilnikov L., Shilnikov L., Shilnikov L., Shilnikov L. P.   +19 more
core   +1 more source

Foreword [PDF]

, 1947
This paper considers identification of unknown parameters in elastic dynamic models of industrial robots. Identifying such models is a challenging task since an industrial robot is a multivariable, nonlinear, resonant, and unstable system.
Moberg, Stig, Wernholt, Erik
core   +2 more sources

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source