Results 71 to 80 of about 517,784 (313)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

An assessment of key model parametric uncertainties in projections of Greenland Ice Sheet behavior [PDF]

, 2012
Lack of knowledge about the values of ice sheet model input parameters introduces substantial uncertainty into projections of Greenland Ice Sheet contributions to future sea level rise.
Stone, Emma J., N. Kirchner, K. Keller, Keller, K., Greve, Ralf, Applegate, P. J., Greve, R., R. Greve, Keller, Klaus, Kirchner, N., Applegate, Patrick J.,, Applegate, Patrick J., Kirchner, Nina, Stone, EJ, Kirchner, Nina,, E. J. Stone, Stone, E. J., P. J. Applegate   +17 more
core   +1 more source

Comparative models in customer base analysis: parametric model and observation-driven model

Journal of Business Economics and Management, 2020
This study conducts a dynamic rolling comparison between the Pareto/NBD model (parametric model) and machine learning algorithms (observation-driven models) in customer base analysis, which the literature has not comprehensively investigated before.
Shao-Ming Xie
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

A New Model to Predict Survival Time in Patients With Hepatocellular Carcinoma With BCLC Advanced Stage

Cancer Medicine
The variety of treatments available makes it difficult to determine whether a treatment would be effective for an individual case in advanced‐stage hepatocellular carcinoma.
Masashi Ninomiya, Mio Tsuruoka, Jun Inoue, Atsushi Hiraoka, Akitoshi Sano, Kosuke Sato, Masazumi Onuki, Satoko Sawahashi, Keishi Ouchi, Kengo Watanabe, Hidekatsu Kuroda, Takayoshi Oikawa, Tamami Abe, Masashi Fujita, Kazumichi Abe, Tomohiro Katsumi, Wataru Sato, Go Igarashi, Chikara Iino, Nobukazu Tanabe, Hiroshi Numao, Hiromasa Ohira, Yoshiyuki Ueno, Atsushi Masamune   +23 more
doaj   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Improving Parametric Mortgage Prepayment Models with Non-parametric Kernel Regression [PDF]

Developing a good prepayment model is a central task in the valuation of mortgages and mortgage-backed securities but conventional parametric models often have bad out-of-sample predictive ability.
Michael Marschoun, Michael LaCour-Little, Clark L. Maxam   +2 more
core  

Parametric sensitivities of the generalized binomial Langevin–multiple mapping conditioning model

, 2021
The binomial Langevin model (BLM) predicts mixture fraction statistics including higher moments excellently, but imposing boundedness for the large scalar spaces typically associated with chemically reacting flows becomes intractable.
D. Bontch-Osmolovskaia, Lindstedt, R Peter, Lindstedt, R. Peter, Andrew P. Wandel, Bontch-Osmolovskaia, D., R. Peter Lindstedt, Bontch-Osmolovskaia, D, du Preez, Matthew, Wandel, Andrew P, Matthew du Preez, Wandel, Andrew P.   +10 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

A Study on Elements of Machine Vision and Machine Learning in Industrial Vision Systems [PDF]

Problemy Mechatroniki
The article presents an analysis of issues regarding the current state and prospects of using machine learning elements in industrial applications of vision systems.
Jarosław PANASIUK (jaroslaw.panasiuk@wat.edu.pl), Adrianna ADAMUS (adrianna.adamus@student.wat.edu.pl)   +1 more
doaj   +1 more source