Results 151 to 160 of about 60,070 (303)

Comparison of NONMEM and pmetrics analysis for aminoglycosides in adult patients with cystic fibrosis

, 2013
The aim of this study was to compare the performance of parametric and nonparametric approaches in population pharmacokinetic analysis for cystic fibrosis patients. The study involved a retrospective analysis of a database of aminoglycoside concentration
Thomson, Alison
core  

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Parametric Modeling And Visualization In Decoding Of Collective Values: From Absolute To Relative Values

Revista Brasileira de Cartografia, 2015
The work herein provides a general discussion on the issues involved in urban and landscape planning, with an emphasis on the visualization. The paper reviews some of the challenges involved in the planning using visualization tools and Geographic ...
Ana Clara Mourão Moura
doaj  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Closing the loop of design and analysis: Parametric modelling tools for early decision support

, 2011
There is a growing need for parametric design software that communicates building performance feedback in early architectural exploration to support decision-making.
J. Frazer, J. Burry, B. Toth, F.Dilys Salim, Salim, Flora, Drogemuller, Robin, Burry, Jane, R. Drogemuller, Toth, Bianca, Frazer, John H.   +9 more
core  

Second-line Treatments for Advanced Gastric Cancer: A Network Meta-Analysis of Overall Survival Using Parametric Modelling Methods. [PDF]

Oncol Ther, 2017
Harvey RC.
europepmc   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Parametric Modelling of the Crystalline Microstructure of the MCM41-Type Mesoporous Silica Modified with Derivatives of Alkyls. [PDF]

Materials (Basel)
Stocki J, Kuśmierz M, Sofińska-Chmiel W, Stankevič M, Puchała M, Kojdecki MA, Gąska R, Grajek H.   +7 more
europepmc   +1 more source

Predicting patient survival after deceased donor kidney transplantation using flexible parametric modelling. [PDF]

BMC Nephrol, 2016
Li B, Cairns JA, Robb ML, Johnson RJ, Watson CJ, Forsythe JL, Oniscu GC, Ravanan R, Dudley C, Roderick P, Metcalfe W, Tomson CR, Bradley JA.   +12 more
europepmc   +1 more source