Results 131 to 140 of about 60,070 (303)

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Digital design exploration of structural morphologies integrating adaptable modules: a design process based on parametric modeling

, 2009
We present an example of parametric modelling of a large span roof and discuss a parametric approach to integrating performance oriented design in the conceptual phase of the design process. In the case study shown here, architectural geometry is related
S. Sariyildiz, M. Turrin, A. Kilian, R. Stouffs   +3 more
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Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Modelling and control of a light-duty hybrid electric truck [PDF]

, 2006
This study is concentrated on modelling and developing the controller for the light-duty hybrid electric truck. The hybrid electric vehicle has advantages in fuel economy.
Park, Jong-Kyu
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Implementation of parametric modelling in façade forming

, 2021
Purpose: The construction sector accounts for a large part of the global greenhouse gasemissions and it is therefore a significant part of the 2030’s environmental goals.Swedens green building council works with environmental certification for ...
Karlsson, Kulchat, Hansson, Agust
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PARAMETRIC 3D MODELING OF I-SHAPE KITCHEN

Journal of Industrial Design and Engineering Graphics, 2019
Interior design is the science and art of enhancing the interior of a space in order to achieve a more aesthetically pleasing and functional environment.
Petar Pejic, Dimitrije Jovanovic, Jovan Marinkovic, Vesna Stojakovic, Sonja Krasic   +4 more
doaj   +2 more sources

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Uncertainty modelling in time-delay systems: Parametric vs. unstructured approach

, 2015
This contribution is focused on comparison of two basic approaches to uncertainty modelling and corresponding robust stability analyses for a system with uncertain time-delay.
Matušů, Radek, Prokop, Roman, Pekař, Libor   +2 more
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