Results 121 to 130 of about 60,070 (303)

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

open access: yesMolecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi   +14 more
wiley   +1 more source

Divergence Between Parametric Income Distributions

open access: yes
Situations often arise in which we are interested in measuring divergence between distributions over time or across regions. This paper proposes an entropy measure of divergence and derives analytical expressions for several parametric distributions ...
Hajargasht, Gholamreza
core   +1 more source

Knowledge-based cost modelling for innovative design [PDF]

open access: yes, 2000
The contribution to new knowledge from this research is a novel method for modelling production costs throughout the design phase of a product's lifecycle, from conceptual to detail design. The provision of cost data throughout the design phase allows
Rehman, S.
core  

A Parametric Modelling Approach for Energy Retrofitting Heritage Buildings: The Case of Amsterdam City Centre

open access: yesEnergies
The city of Amsterdam has ambitious goals to achieve a 95% reduction in carbon emissions by 2050 and to phase out natural gas by 2040. Disconnecting the building stock from natural gas requires well-ventilated and well-insulated buildings and a switch to
Maéva Dang   +2 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

open access: yesMolecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir   +13 more
wiley   +1 more source

Using multinomial and imprecise probability for non-parametric modelling of rainfall in Manizales (Colombia)

open access: yesIngeniería e Investigación, 2008
This article presents a rainfall model constructed by applying non-parametric modelling and imprecise probabilities; these tools were used because there was not enough homogeneous information in the study area.
Ibsen Chivatá Cárdenas
doaj  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

open access: yesMolecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski   +10 more
wiley   +1 more source

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