Results 111 to 120 of about 60,070 (303)
Computational Design and Optimization of Discrete Shell Structures Made of Equivalent Members
BuildingsThis paper presents a computational design method for generating discrete shell structures using sets of equivalent discrete members. This study addresses the challenge of reducing the geometrical variety in discrete shell elements by introducing a ...
Arda Ağırbaş, Seçkin Kutucu
doaj +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Structural studies into AM(_2)O(_7) framework materials and parametric Rietveld refinement [PDF]
, 2006 This thesis investigates the structural properties of the AM2O7 family of materials, many of which show interesting thermal expansion properties and remarkably complex structures.
Stinton, Graham William
core
Interactive Iconized Grammar‐Based Pailou Modelling
, 2020 Pailous are representative Chinese architectural works used for commemoration. However, their geometric structure and semantic construction rules are too complex for quick and intuitive modelling using traditional modelling tools. We propose an intuitive
Lai, Yu‐Chi +4 more
core +1 more source
Longitudinal Data Regression Analysis Using Semiparametric Modelling
Revstat Statistical JournalZhang, Leng and Tang (2015) propose joint parametric modelling of the means, variances, and the correlations by decomposing the correlation matrix via hyperspherical co-ordinates and show that this results unconstrained parameterization, fast ...
Abdulla Mamun, Sudhir Paul
doaj
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Semi-parametric Models for Satisfaction with Income
An overview is presented of some parametric and semi-parametric models, estimators, and specification tests that can be used to analyze ordered response variables.In particular, limited dependent variable models that generalize or-dered probit are ...
Bellemare, C. +2 more
core
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
BuildingsUnderstanding energy demand and supply flow at a large urban scale is an essential step for urban designers, planners and policymakers in investigating how buildings within an existing urban context could be designed as a whole to support the future ...
Jihyun Park, Tsung-Hsien Wang
doaj +1 more source