Results 121 to 130 of about 327,869 (262)

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Construction of complex non-uniform rational B-spline volume parametric models with G¹ continuity. [PDF]

Vis Comput Ind Biomed Art
Wang D, Chen L, Zhang J.
europepmc   +1 more source

Broadband lung dielectric properties over the ablative temperature range: Experimental measurements and parametric models. [PDF]

Med Phys, 2019
Sebek J, Bortel R, Prakash P.
europepmc   +1 more source

The relative survival and cure fraction of gastric cancer estimated through flexible parametric models using data from population-based cancer registration during 2003-2012 in Linzhou, China. [PDF]

Cancer Med, 2020
Chen Q, Liu SZ, Zhang SK, Cao XQ, Li BY, Quan PL, Guo LW, Dong L, Sun XB, Zhang Y, Zhang JG.   +10 more
europepmc   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

BSD: A Bayesian Framework for Parametric Models of Neural Spectra. [PDF]

Eur J Neurosci
Medrano J, Alexander NA, Seymour RA, Zeidman P.   +3 more
europepmc   +1 more source

Parametric models for biomarkers based on flexible size distributions. [PDF]

Health Econ, 2018
Davillas A, Jones AM.
europepmc   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Prediction of mixture toxicity of essential oil constituents using nonparametric and parametric models against Musca domestica L. [PDF]

Pest Manag Sci
Yoon J, Tak JH.
europepmc   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source