Results 61 to 70 of about 379,530 (310)
طب کار, 2018 Introduction: Respiratory diseases are one of the most common occupational diseases in Iran. This study aimed to investigate the factors affecting the time of development of pulmonary restrictive patterns in the workerschr('39') spirometry in Yazd tile ...
Mohsen Askarishahi +3 more
doaj
Modeling Tropical Cyclone Boundary Layer Wind Fields over Ocean and Land: A Comparative Assessment
AtmosphereAccurate simulation of boundary layer wind field structures is essential for evaluating tropical cyclone (TC) wind hazards and supporting engineering design in coastal regions.
Jian Yang +3 more
doaj +1 more source
Parametric model-based clustering [PDF]
SPIE Proceedings, 2005 Parametric, model-based algorithms learn generative models from the data, with each model corresponding to one particular cluster. Accordingly, the model-based partitional algorithm will select the most suitable model for any data object (Clustering step}, and will recompute parametric models using data specifically from the corresponding clusters ...
Nikulin, Vladimir, Smola, Alexander
openaire +3 more sources
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Interval Estimation of Value-at-Risk Based on Nonparametric Models
Econometrics, 2018 Value-at-Risk (VaR) has become the most important benchmark for measuring risk in portfolios of different types of financial instruments. However, as reported by many authors, estimating VaR is subject to a high level of uncertainty.
Hussein Khraibani +2 more
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Beta-Stacy survival regression models [PDF]
, 2007 This paper introduces a class of survival models for discrete time-to-event data with random right censoring. Flexible distributions for the survival times are constructed by modelling the random survival functions as discrete-time beta-Stacy processes (
Muliere, Pietro, Rigat, Fabio
core
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Semiparametric Multinomial Logit Models for Analysing Consumer Choice Behaviour [PDF]
, 2006 The multinomial logit model (MNL) is one of the most frequently used statistical models in marketing applications. It allows to relate an unordered categorical response variable, for example representing the choice of a brand, to a vector of covariates ...
Steiner, Winfried J. +2 more
core +1 more source