Results 61 to 70 of about 93,288 (302)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
New Journal of Physics, 2019 The existing widely-accepted theory of photon-pair generation via spontaneous down-conversion (SPDC) in nonlinear optical crystals and waveguides is incomplete, as it fails to account for the important physical phenomenon of parametric resonances.
Philip B Main +2 more
doaj +1 more source
Parametric resonance in metallic bellows connected to pipe due to seismic excitation
Nihon Kikai Gakkai ronbunshu, 2015 This paper discusses the parametric resonance of the metallic bellows which is connected to the fluid filled pipe subjected to the seismic excitation. The axial stiffness of the metallic bellows varies due to the internal fluid pressure variation, and ...
Tomoya YORIKI +2 more
doaj +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Photonics, 2019 The achievement of wideband high-gain optical parametric amplification has not been shown in micrometer-scale cavities. In this paper we have computationally investigated the optical parametric amplification process in a few micrometer-long dispersive ...
Özüm Emre Aşırım +1 more
doaj +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
INFLUENCE OF AXIAL GUIDING MAGNETIC FIELD ON AMPLIFICATION OF WAVES IN A PLASMA-BEAM SUPERHETERODYNE FREE ELECTRON LASER OF DOPPLERTRONE TYPE [PDF]
Радиофизика и электроника, 2017 The research subject is the amplification characteristics of the plasma-beam superheterodyne free-electron laser of the dopplertron type. The purpose is to theoretically investigate the influence of longitudinal magnetic field on the wave amplification ...
A. V. Lysenko +2 more
doaj +1 more source
Parametric Resonance of Magnetization Excited by Electric Field. [PDF]
Nano letters (Print), 2016 Manipulation of magnetization by electric field is a central goal of spintronics because it enables energy-efficient operation of spin-based devices. Spin wave devices are promising candidates for low-power information processing, but a method for energy-
Yu-Jin Chen +8 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source