Results 101 to 110 of about 32,943,257 (245)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
The Influence of the Thickness of the Slab and Concrete Grade on Composite Floors
Bulletin of the Polytechnic Institute of Jassy: Constructions, Architechture Section, 2010 A modern flooring system is the ComFloor Composite Floor Deck from Corus. This type of floor has many advantages involving cost, weight, construction speed, but also disadvantages regarding vibrations induced by human activity. The vibration behaviour of
Vasile-Mircea Venghiac, Cedric D’Mello
doaj
Applied SciencesThis study presents an analytical investigation and a parametric evaluation of the structural behavior and seismic performance of highly corroded reinforced concrete (RC) columns, based on previously conducted experimental studies by the authors.
Alper Çelik +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
BuildingsThis study presents a systematic investigation into the seismic performance of precast concrete shear walls using cold-extruded sleeve connections for reinforcement splicing.
Guang-Bin Pan, Ying-Rui Chen, Jian Cai
doaj +1 more source
Affordability Assessment for a Subsonic Transport
, 1999 Presented at the 2nd Joint ISPA/SCEA International Conference, San Antonio, TX, June 1999.Military budget cuts and increased competition in the commercial market have shifted the focus of aircraft design to include affordability concerns.
Mavris, Dimitri N., Garcia, Elena
core
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Optical parametric oscillators : a comparison of new materials [PDF]
, 2015 A study of new materials for optical parametric oscillators (OPOs) was carried out using an XeCI excimer laser as a pump source. The three non-linear optical materials studied were lithium borate (LBO), deuterated L-arginine phosphate (d-LAP) and β ...
Robertson, Gordon
core +1 more source
A new bridge-vehicle system - part II: Parametric study
, 2003 The formulation of a new bridge-vehicle system using shell with eccentric beam elements has been introduced in a companion paper (Part 1). The new system takes into account of the contribution of the twisting and pitching modes of vehicles to the bridge ...
Yu, L +7 more
core
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source