Results 81 to 90 of about 90,366 (260)
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Case variation in coordination: Danish vs. Faroese
Nordlyd: Tromsø University Working Papers on Language & Linguistics, 2009 This paper is primarily concerned with inter- and intra-individually variable case-form mismatches inside coordinate determiner phrases (CoDPs). For English, the phenomenon is both socially salient (e.g., O'Conner & Kellerman 2009, among many others) and
Jeffrey K. Parrott
doaj +1 more source
Generation and dynamics of entangled fermion–photon–phonon states in nanocavities
Nanophotonics, 2020 We develop the analytic theory describing the formation and evolution of entangled quantum states for a fermionic quantum emitter coupled simultaneously to a quantized electromagnetic field in a nanocavity and quantized phonon or mechanical vibrational ...
Tokman Mikhail +4 more
doaj +1 more source
Dirac quantization of parametrized field theory [PDF]
Physical Review D, 2007 33 ...
openaire +2 more sources
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Nature CommunicationsWe present a general class of machine learning algorithms called parametric matrix models. In contrast with most existing machine learning models that imitate the biology of neurons, parametric matrix models use matrix equations that emulate physical ...
Patrick Cook +4 more
doaj +1 more source
A Computer Algebra Approach to Linear ODE Systems with Parametric Coefficients [PDF]
Control and Optimization in Applied MathematicsThis paper analyzes systems of linear first-order ordinary differential equations (ODEs) with parametric coefficients, a class of problems that arises in control theory, optimization, and applied mathematics.
Mahdi Dehghani Darmian
doaj +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
A Presheaf Model of Parametric Type Theory
Electronic Notes in Theoretical Computer Science, 2015 AbstractWe extend Martin-Löf's Logical Framework with special constructions and typing rules providing internalized parametricity. Compared to previous similar proposals, this version comes with a denotational semantics which is a refinement of the standard presheaf semantics of dependent type theory. Further, this presheaf semantics is a refinement of
Jean-Philippe Bernardy +2 more
openaire +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source